ArticleCancer causes & control : CCC2012
Dietary B vitamin and methionine intakes and lung cancer risk among female never smokers in China.
Article in Cancer causes & control : CCC, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Serum Folate Levels and Lung Cancer Risk: A Meta- Epidemiological Study of Population-based Case-Control Studies.Asian Pacific journal of cancer prevention : APJCP · 2020Pooled it
- Association between folate intake and the risk of lung cancer: a dose-response meta-analysis of prospective studies.PloS one · 2014Pooled it
- Etiology and risk factors for lung cancer in female Asian never smokers: a systematic review.Therapeutic advances in medical oncology · 2026Review
- Fruit and Vegetable Intake in Relation to Lung Cancer Risk: A Systematic Review and Dose-response Meta-analysis of Prospective Cohort Studies.Journal of cancer prevention · 2025Review
- Recent Advances on the Role of B Vitamins in Cancer Prevention and Progression.International journal of molecular sciences · 2025Review
- Micronutrients Importance in Cancer Prevention-Vitamins.Cancer treatment and research · 2024Review
- Bioactive Ingredients from Dairy-Based Lactic Acid Bacterial Fermentations for Functional Food Production and Their Health Effects.Nutrients · 2023Review
- Mechanism of Taxanes in the Treatment of Lung Cancer Based on Network Pharmacology and Molecular Docking.Current issues in molecular biology · 2023Article
- Association Between Riboflavin Intake and Telomere Length: A Cross-Sectional Study From National Health and Nutrition Examination Survey 1999-2002.Frontiers in nutrition · 2022Article
- The association between dietary vitamin B12 and lung cancer risk: findings from a prospective cohort study.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2021Article
- B Vitamins and Their Role in Immune Regulation and Cancer.Nutrients · 2020Review
- Food intake of folate, folic acid and other B vitamins with lung cancer risk in a low-income population in the Southeastern United States.European journal of nutrition · 2020Article
- Riboflavin: The Health Benefits of a Forgotten Natural Vitamin.International journal of molecular sciences · 2020Review
- Update on Safety Profiles of Vitamins B1, B6, and B12: A Narrative Review.Therapeutics and clinical risk management · 2020Review
- Folate food source, usual intake, and folate status in Korean adults.Nutrition research and practice · 2018Article
- Association of One-Carbon Metabolism-Related Vitamins (Folate, B6, B12), Homocysteine and Methionine With the Risk of Lung Cancer: Systematic Review and Meta-Analysis.Frontiers in oncology · 2018Article
- Long-Term, Supplemental, One-Carbon Metabolism-Related Vitamin B Use in Relation to Lung Cancer Risk in the Vitamins and Lifestyle (VITAL) Cohort.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2017Article
- Higher dietary intakes of choline and betaine are associated with a lower risk of primary liver cancer: a case-control study.Scientific reports · 2017Article
- Dietary Reference Values for vitamin B6.EFSA journal. European Food Safety Authority · 2016Article
- Cancer incidence in urban Shanghai, 1973-2010: an updated trend and age-period-cohort effects.BMC cancer · 2016Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
purposeB vitamins and methionine have been postulated to have potential effects on carcinogenesis; however, findings from previous epidemiologic studies on B vitamins, methionine, and lung cancer risk are inconsistent. We investigated associations of dietary intakes of B vitamins (i.e., riboflavin, niacin, vitamin B6, folate, and vitamin B12) and methionine with lung cancer risk among female never smokers.
methodsThe Shanghai Women's Health Study, a population-based, prospective cohort study, included 74,941 women. During a median follow-up of 11.2 years, 428 incident lung cancer cases accrued among 71,267 women with no history of smoking or cancer at baseline. Baseline dietary intakes were derived from a validated, interviewer-administered food frequency questionnaire. Cancer incidence and vital status were ascertained through annual linkage to the Shanghai Cancer Registry and Shanghai Vital Statistics Registry databases and through biennial in-person follow-ups with participants. Adjusted hazard ratios (HR) and 95 % confidence intervals (CI) were calculated using Cox regression.
resultsDietary riboflavin intake was inversely associated with lung cancer risk (HR = 0.62; 95 % CI = 0.43-0.89; p trend = 0.03 for the highest quartile compared with the lowest). A higher than median intake of methionine was associated with lower risk of lung cancer (HR = 0.78; 95 % CI = 0.60-0.99); however, there was no dose-response relation. Intakes of other B vitamins were not associated with lung cancer risk.
conclusionsOur study suggests that dietary riboflavin intake may be inversely associated with lung cancer risk among female never smokers, which warrants further investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.