ArticleAmerican journal of physiology. Lung cellular and molecular physiology2012
Novel aspects of urokinase function in the injured lung: role of α2-macroglobulin.
Article in American journal of physiology. Lung cellular and molecular physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Liver-Dependent Lung Remodeling during Systemic Inflammation Shapes Responses to Secondary Infection.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Dietary plant extracts modulate gene expression profiles in alveolar macrophages of pigs experimentally infected with porcine reproductive and respiratory syndrome virus.Journal of animal science and biotechnology · 2020Article
- Perfluorochemical-facilitated plasminogen activator delivery to the airways: A novel treatment for inhalational smoke-induced acute lung injury.Clinical and translational medicine · 2020Article
- Lack of durable protection against cotton smoke-induced acute lung injury in sheep by nebulized single chain urokinase plasminogen activator or tissue plasminogen activator.Clinical and translational medicine · 2018Article
- Ex Vivo Lung Perfusion Model to Study Pulmonary Tissue Extracellular Microvesicle Profiles.The Annals of thoracic surgery · 2017Article
- The fibrogenic actions of lung fibroblast-derived urokinase: a potential drug target in IPF.Scientific reports · 2017Article
- The time course of resolution of adhesions during fibrinolytic therapy in tetracycline-induced pleural injury in rabbits.American journal of physiology. Lung cellular and molecular physiology · 2015Article
- Article
- Active α-macroglobulin is a reservoir for urokinase after fibrinolytic therapy in rabbits with tetracycline-induced pleural injury and in human pleural fluids.American journal of physiology. Lung cellular and molecular physiology · 2013Article
- Remarkable stabilization of plasminogen activator inhibitor 1 in a "molecular sandwich" complex.Biochemistry · 2013Article
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
The level of active urokinase (uPA) is decreased in lung fluids of patients with acute lung injury/acute respiratory distress syndrome (ALI/ARDS) whereas α(2)-macroglobulin (α(2)-M), a plasma proteinase inhibitor, is a major component of these fluids. Since there have been reports describing the ability of α(2)-M to form complexes with uPA in vitro, we hypothesized that α(2)-M may interact with uPA in the lung to modulate its biological activity. Pulmonary edema fluids and lung tissues from patients with ALI/ARDS were evaluated for the presence of uPA associated with α(2)-M. Complexes between α(2)-M and uPA were detected in alveolar edema fluids as well as in lungs of patients with ALI/ARDS where they were located mainly in close proximity to epithelial cells. While uPA bound to α(2)-M retains its amidolytic activity towards low-molecular-weight substrates, it is not inhibited by its main physiological inhibitor, plasminogen activator inhibitor 1. We also investigated the functional consequences of formation of complexes between uPA and α(2)-M in vitro. We found that when α(2)-M:uPA complexes were added to cultures of human bronchial epithelial cells (BEAS-2B), activation of nuclear factor-κB as well as production of interleukin-6 and -8 was substantially suppressed compared with the addition of uPA alone. Our findings indicate for the first time that the function of uPA in patients with ALI/ARDS may be modulated by α(2)-M and that the effects may include the regulation of the fibrinolytic and signaling activities of uPA.
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