Evidence map›Paper›PMID 23064885›Full record

SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2013

Topical agent therapy for prevention and treatment of radiodermatitis: a meta-analysis.

Yuejiao Zhang, Shoude Zhang, Xiaoling Shao

Abstract readMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 4 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 4 syntheses or guidelines pooled it, 67 citations in OpenAlex.

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  3. Topical interventions to prevent acute radiation dermatitis in head and neck cancer patients: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yuejiao ZhangDepartment of VIP Ward, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, People's Republic of China. z2zhangyj@126.com
Shoude Zhang
Xiaoling Shao
Second Affiliated Hospital of Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRadiodermatitis (RD) is a common side effect during radiotherapy. Various topical agents have been tried to be applied on RD. However, the efficiency of topical agents applied on radiotherapy is still uncertain.

objectiveThis study aims to assess the efficiency of the topical agents in the prevention and treatment of RD.

methodsThe Cochrane Central Register of Controlled Trials, Pubmed, and Medline were searched for relevant reports. Quantitative analysis was carried out to evaluate the efficiency of topical agents in the prevention and treatment of RD.

resultsTwenty reports involving 3,098 patients were included: 2,406 patients for prophylactic trials and 692 for treatment trials, respectively. For prophylactic trials, primary meta-analysis indicated that using topical agents could not reduce the incidence of grade 2 and higher RD (P = 0.128, RR = 0.90, 95 % CI = 0.78-1.03) with a high heterogeneity (P = 0.000, I(2) = 71.5 %). In subgroup analyses, heterogeneity disappeared by excluding reports with low Jadad score (≤3) (P = 0.292, I(2) = 15.2 %), and still no significant difference was found between the topical agent group and control group (P = 0.625, RR = 0.98, 95 % CI = 0.89-1.07). In addition, for treatment trials, topical agents failed to increase the incidence of wound healing (P = 0.784, RR = 1.01, 95 % CI = 0.92-1.12) with a high heterogeneity (P = 0.067, I (2) = 51.5 %).

conclusionsTopical agents could not prevent or treat RD effectively. New type of agents should be developed to improve the efficiency based on the pathophysiology of RD.

Indexed as

Administration, TopicalAdultAgedConfidence IntervalsEvaluation Studies as TopicHumansMiddle AgedNeoplasmsRadiodermatitisRandomized Controlled Trials as Topic

Identifiers

PMID23064885
OpenAlexW2167113255

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.