ArticleInternational journal of legal medicine2013
Diagnostic value of lipopolysaccharide-binding protein and procalcitonin for sepsis diagnosis in forensic pathology.
Article in International journal of legal medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Postmortem Blood Procalcitonin (PCT) for identifying sepsis as a cause of death: a systematic review and meta-analysis.International journal of legal medicine · 2026Review
- Post-Mortem Investigations for the Diagnosis of Sepsis: A Review of Literature.Diagnostics (Basel, Switzerland) · 2020Review
- Sepsis and Nosocomial Infections: The Role of Medico-Legal Experts in Italy.Antibiotics (Basel, Switzerland) · 2019Review
- A diabetic ketoacidosis in a context of hyperglycemia addiction.International journal of legal medicine · 2018Article
- A Pathophysiological Insight into Sepsis and Its Correlation with Postmortem Diagnosis.Mediators of inflammation · 2016Review
- Postmortem serum protein growth arrest-specific 6 levels in sepsis-related deaths.International journal of legal medicine · 2015Article
- Procalcitonin as a postmortem sepsis marker. A comparison of the validity of results obtained from blood serum, aqueous humour and cerebrospinal fluid.International journal of legal medicine · 2015Article
- Markers for sepsis diagnosis in the forensic setting: state of the art.Croatian medical journal · 2014Review
- Preliminary results on the postmortem measurement of 3-beta-hydroxybutyrate in liver homogenates.International journal of legal medicine · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aims of this study were twofold. The first was to investigate the diagnostic performance of two biochemical markers, procalcitonin (PCT) and lipopolysaccharide-binding protein (LBP), considering each individually and then combined, for the postmortem diagnosis of sepsis. We also tested the usefulness of pericardial fluid for postmortem LBP determination. Two study groups were formed, a sepsis-related fatalities group of 12 cases and a control group of 30 cases. Postmortem native CT scans, autopsy, histology, neuropathology, and toxicology as well as other postmortem biochemical investigations were performed in all cases. Microbiological investigations were also carried out in the septic group. Postmortem serum PCT and LBP levels differed between the two groups. Both biomarkers, individually considered, allowed septic states to be diagnosed, whereas increases in both postmortem serum PCT and LBP levels were only observed in cases of sepsis. Similarly, normal PCT and LBP values in postmortem serum were identified only in non-septic cases. Pericardial fluid LBP levels do not correlate with the presence of underlying septic states. No relationship was observed between postmortem serum and pericardial fluid LBP levels in either septic or non-septic groups, or between pericardial fluid PCT and LBP levels.
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Registered trials
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