ArticleJournal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology2013
Glutamate evokes firing through activation of kainate receptors in chick accessory lobe neurons.
Article in Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- The Balance Hypothesis for the Avian Lumbosacral Organ and an Exploration of Its Morphological Variation.Integrative organismal biology (Oxford, England) · 2020Article
- 3D Anatomy of the Quail Lumbosacral Spinal Canal-Implications for Putative Mechanosensory Function.Integrative organismal biology (Oxford, England) · 2020Article
- Activation of muscarinic acetylcholine receptors elevates intracellular Ca(2+) concentrations in accessory lobe neurons of the chick.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2015Article
- Voltage-gated Ca2+ channels in accessory lobe neurons of the chick.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2014Article
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Authors and funding
5 authors at 2 institutions in 1 country.
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Abstract
Ten pairs of protrusions, called accessory lobes (ALs), exist at the lateral sides of avian lumbosacral spinal cords. Histological and behavioral evidence suggests that neurons are present in ALs and the AL acts as a sensory organ of equilibrium during walking. Neurons in the outer layer of the AL consistently show glutamate-like immunoreactivity and neurons in the central region of the AL show glutamate receptor-like immunoreactivity. However, it is unknown how glutamate acts on the functional activity of AL neurons. In this study, we examined the effects of glutamate on the electrical activities of AL neurons using the patch clamp technique. There are two types of neurons among isolated AL neurons: spontaneously firing and silent neurons. Among silent neurons, 42 % of neurons responded to glutamate and generated repetitive firing. Kainate and glutamate in combination with the NMDA receptor antagonist, MK-801, also induced firing and evoked an inward current. On the other hand, the application of AMPA, NMDA or glutamate in combination with the non-NMDA receptor antagonist, CNQX, did not. These results indicate that chick AL neurons express functional kainate receptors to respond to glutamate and suggest that the glutamatergic transmission plays a role in excitatory regulation of AL neurons of the chick.
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