ArticleLung2012
Early identification of small airways disease on lung cancer screening CT: comparison of current air trapping measures.
Article in Lung, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 63 citations in OpenAlex.
- Article
- Preserved ratio impaired spirometry: clinical, imaging and artificial intelligence perspective.Journal of thoracic disease · 2025Review
- Computed Tomography Lung Density Analysis: An Imaging Biomarker Predicting Physical Inactivity in Chronic Obstructive Pulmonary Disease: A Pilot Study.Journal of clinical medicine · 2023Article
- Quantitative CT lung densitometry as an obstructive marker for the diagnosis of bronchiolitis obliterans in children.PloS one · 2022Article
- Article
- Air trapping in usual interstitial pneumonia pattern at CT: prevalence and prognosis.Scientific reports · 2018Article
- Unilateral Chronic Lung Allograft Dysfunction Assessed by Biphasic Computed Tomographic Volumetry in Bilateral Living-donor Lobar Lung Transplantation.Transplantation direct · 2018Article
- Relationship of CT-quantified emphysema, small airways disease and bronchial wall dimensions with physiological, inflammatory and infective measures in COPD.Respiratory research · 2018Observational
- Time to Exhale: Additional Value of Expiratory Chest CT in Chronic Obstructive Pulmonary Disease.Canadian respiratory journal · 2018Article
- Quantitative computed tomography features and clinical manifestations associated with the extent of bronchiectasis in patients with moderate-to-severe COPD.International journal of chronic obstructive pulmonary disease · 2018Article
- Signs of Gas Trapping in Normal Lung Density Regions in Smokers.American journal of respiratory and critical care medicine · 2017Article
- Quantitative computed tomography measurements to evaluate airway disease in chronic obstructive pulmonary disease: Relationship to physiological measurements, clinical index and visual assessment of airway disease.European journal of radiology · 2016Review
- Normal spectrum of pulmonary parametric response map to differentiate lung collapsibility: distribution of densitometric classifications in healthy adult volunteers.European radiology · 2016Article
- Landmark papers in respiratory medicine: Automatic quantification of emphysema and airways disease on computed tomography.Breathe (Sheffield, England) · 2016Article
- Smokers with emphysema and small airway disease on computed tomography have lower bone density.International journal of chronic obstructive pulmonary disease · 2016Article
- Article
- [Diseases of the airways].Der Radiologe · 2014Article
- Relationship between CT air trapping criteria and lung function in small airway impairment quantification.BMC pulmonary medicine · 2014Article
- Development of quantitative computed tomography lung protocols.Journal of thoracic imaging · 2013Review
- Quantitative computed tomography in chronic obstructive pulmonary disease.Journal of thoracic imaging · 2013Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLung cancer screening CT scans might provide valuable information about air trapping as an early indicator of smoking-related lung disease. We studied which of the currently suggested measures is most suitable for detecting functionally relevant air trapping on low-dose computed tomography (CT) in a population of subjects with early-stage disease.
methodsThis study was ethically approved and informed consent was obtained. Three quantitative CT air trapping measures were compared against a functional reference standard in 427 male lung cancer screening participants. This reference standard for air trapping was derived from the residual volume over total lung capacity ratio (RV/TLC) beyond the 95th percentile of predicted. The following CT air trapping measures were compared: expiratory to inspiratory relative volume change of voxels with attenuation values between -860 and -950 Hounsfield Units (RVC(-860 to -950)), expiratory to inspiratory ratio of mean lung density (E/I-ratio(MLD)) and percentage of voxels below -856 HU in expiration (EXP(-856)). Receiver operating characteristic (ROC) analysis was performed and area under the ROC curve compared.
resultsFunctionally relevant air trapping was present in 38 (8.9 %) participants. E/I-ratio(MLD) showed the largest area under the curve (0.85, 95 % CI 0.813-0.883), which was significantly larger than RVC(-860 to -950) (0.703, 0.657-0.746; p < 0.001) and EXP(-856) (0.798, 0.757-0.835; p = 0.002). At the optimum for sensitivity and specificity, E/I-ratio(MLD) yielded an accuracy of 81.5 %.
conclusionsThe expiratory to inspiratory ratio of mean lung density (E/I-ratio(MLD)) is most suitable for detecting air trapping on low-dose screening CT and performs significantly better than other suggested quantitative measures.
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