ArticleNeurobiology of disease2013
Altered short-term plasticity in the prefrontal cortex after early life seizures.
Article in Neurobiology of disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 47 citations in OpenAlex.
- The Burden of Epilepsy: The Contribution of Seizures (AES 2025 Presidential Symposium).Epilepsy currents · 2026Article
- Rapamycin and Minocycline Treatment Does Not Rescue Behavioral and Molecular Changes Induced by Early-Life Seizures in Female Mice.NeuroSci · 2026Article
- Timing is everything: The effect of early-life seizures on developing neuronal circuits subserving spatial memory.Epilepsia open · 2025Review
- Efficacy and Safety of Neuromodulation Interventions for Autism Spectrum Disorders with Comorbidities: A Systematic Review.Neuropsychiatric disease and treatment · 2025Review
- Alterations of Neuronal Dynamics as a Mechanism for Cognitive Impairment in Epilepsy.Current topics in behavioral neurosciences · 2022Review
- Mechanisms for Cognitive Impairment in Epilepsy: Moving Beyond Seizures.Frontiers in neurology · 2022Review
- Shared Etiology in Autism Spectrum Disorder and Epilepsy with Functional Disability.Behavioural neurology · 2022Review
- Development of prefrontal cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Epileptic seizures in a heterogeneous excitatory network with short-term plasticity.Cognitive neurodynamics · 2021Article
- Normalization enhances brain network features that predict individual intelligence in children with epilepsy.PloS one · 2019Article
- Regulation of seizure-induced MeCP2 Ser421 phosphorylation in the developing brain.Neurobiology of disease · 2018Article
- Anatomy Based Networks and Topology Alteration in Seizure-Related Cognitive Outcomes.Frontiers in neuroanatomy · 2018Review
- Brain Network Architecture and Global Intelligence in Children with Focal Epilepsy.AJNR. American journal of neuroradiology · 2017Article
- Metrics of brain network architecture capture the impact of disease in children with epilepsy.NeuroImage. Clinical · 2017Article
- Why Are Children With Epileptic Encephalopathies Encephalopathic?Journal of child neurology · 2016Review
- Effect of Seizures on the Developing Brain and Cognition.Seminars in pediatric neurology · 2016Review
- Epilepsy and Autism.Cold Spring Harbor perspectives in medicine · 2016Review
- Mechanisms Responsible for Cognitive Impairment in Epilepsy.Cold Spring Harbor perspectives in medicine · 2015Review
- Alterations in sociability and functional brain connectivity caused by early-life seizures are prevented by bumetanide.Neurobiology of disease · 2015Article
- Visual experience prevents dysregulation of GABAB receptor-dependent short-term depression in adult superior colliculus.Journal of neurophysiology · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 3 countries.
Funding
Abstract
Seizures during development are a relatively common occurrence and are often associated with poor cognitive outcomes. Recent studies show that early life seizures alter the function of various brain structures and have long-term consequences on seizure susceptibility and behavioral regulation. While many neocortical functions could be disrupted by epileptic seizures, we have concentrated on studying the prefrontal cortex (PFC) as disturbance of PFC functions is involved in numerous co-morbid disorders associated with epilepsy. In the present work we report an alteration of short-term plasticity in the PFC in rats that have experienced early life seizures. The most robust alteration occurs in the layer II/III to layer V network of neurons. However short-term plasticity of layer V to layer V network was also affected, indicating that the PFC function is broadly influenced by early life seizures. These data strongly suggest that repetitive seizures early in development cause substantial alteration in PFC function, which may be an important component underlying cognitive deficits in individuals with a history of seizures during development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.