ArticleThe Plant cell2012
Non-recognition-of-BTH4, an Arabidopsis mediator subunit homolog, is necessary for development and response to salicylic acid.
Article in The Plant cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 128 citations in OpenAlex.
- Article
- Article
- CDK8 phosphorylation of DELLA limits Mediator recruitment in gibberellin signaling.bioRxiv : the preprint server for biology · 2026Article
- Mediator subunit MED25 represses ABI5-dependent activation of erucic acid biosynthetic geneFrontiers in plant science · 2026Article
- Genetic suppressors of the growth-immunity trade-off in the Arabidopsis salicylic acid-accumulating dmr6 dlo1 mutant.The Plant journal : for cell and molecular biology · 2025Article
- Genome-Wide Identification and Functional Characterization of Brown Spot Resistance Genes in Rice (Journal of agricultural and food chemistry · 2025Article
- Salicylic acid accumulation: emerging molecular players and novel perspectives on plant development and nutrition.Journal of experimental botany · 2025Review
- Collaboration between DELLA proteins and the Mediator subunit MED15 to regulate transcription in plants.Journal of experimental botany · 2025Article
- RhMED15a-like, a subunit of the Mediator complex, is involved in the drought stress response in Rosa hybrida.BMC plant biology · 2024Article
- The Mediator Subunit OsMED16 Interacts with the WRKY Transcription Factor OsWRKY45 to Enhance Rice Resistance Against Magnaporthe oryzae.Rice (New York, N.Y.) · 2024Article
- A Mediator subunit imparts robustness to a polyphenism decision.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- MEDIATOR SUBUNIT 16 negatively regulates rice immunity by modulating PATHOGENESIS RELATED 3 activity.Plant physiology · 2023Article
- Genome-wide analysis of KIX gene family for organ size regulation in soybean (Frontiers in plant science · 2023Article
- Transcriptional Coactivators: Driving Force of Plant Immunity.Frontiers in plant science · 2022Review
- The THO/TREX Complex Active in Alternative Splicing Mediates Plant Responses to Salicylic Acid and Jasmonic Acid.International journal of molecular sciences · 2021Article
- Small RNA profiling for identification of microRNAs involved in regulation of seed development and lipid biosynthesis in yellowhorn.BMC plant biology · 2021Article
- The Arabidopsis mediator complex subunit 8 regulates oxidative stress responses.The Plant cell · 2021Article
- Overexpression of ZmWRKY65 transcription factor from maize confers stress resistances in transgenic Arabidopsis.Scientific reports · 2021Article
- Article
- Functional Analysis ofFrontiers in plant science · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Salicylic acid (SA) signaling acts in defense and plant development. The only gene demonstrated to be required for the response to SA is Arabidopsis thaliana non-expresser of pathogenesis-related gene 1 (NPR1), and npr1 mutants are insensitive to SA. By focusing on the effect of analogs of SA on plant development, we identified mutants in additional genes acting in the SA response. In this work, we describe a gene necessary for the SA Non-Recognition-of-BTH4 (NRB4). Three nrb4 alleles recovered from the screen cause phenotypes similar to the wild type in the tested conditions, except for SA-related phenotypes. Plants with NRB4 null alleles express profound insensitivity to SA, even more than npr1. NRB4 null mutants are also sterile and their growth is compromised. Plants carrying weaker nrb4 alleles are also insensitive to SA, with some quantitative differences in some phenotypes, like systemic acquired resistance or pathogen growth restriction. When weak alleles are used, NPR1 and NRB4 mutations produce an additive phenotype, but we did not find evidence of a genetic interaction in F1 nor biochemical interaction in yeast or in planta. NRB4 is predicted to be a subunit of Mediator, the ortholog of MED15 in Arabidopsis. Mechanistically, NRB4 functions downstream of NPR1 to regulate the SA response.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.