Evidence map›Paper›PMID 23064154›Full record

ReviewRNA biology2013

Rarely at rest: RNA helicases and their busy contributions to RNA degradation, regulation and quality control.

Steven W Hardwick, Ben F Luisi

Open access · hybridAbstract readReview
In one paragraph

Review in RNA biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Regulation of pluripotency and reprogramming by RNA binding proteins.Current topics in developmental biology · 2020
    Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. RNA search engines empower the bacterial intranet.Biochemical Society transactions · 2017
    Review
  11. Article
  12. Article
  13. The regulation and functions of the nuclear RNA exosome complex.Nature reviews. Molecular cell biology · 2016
    Review
  14. Article
  15. RNA helicase proteins as chaperones and remodelers.Annual review of biochemistry · 2014
    Review
  16. Review
  17. Article
  18. Article
  19. Emerging relationship between RNA helicases and autophagy.Journal of Zhejiang University. Science. B
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Steven W HardwickDepartment of Biochemistry, University of Cambridge, Cambridge, UK.
Ben F Luisi
University of Cambridge · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

RNA helicases are compact, machine-like proteins that can harness the energy of nucleoside triphosphate binding and hydrolysis to dynamically remodel RNA structures and protein-RNA complexes. Through such activities, helicases participate in virtually every process associated with the expression of genetic information. Often found as components of multi-enzyme assemblies, RNA helicases facilitate the processivity of RNA degradation, the remodeling of protein interactions during maturation of structured RNA precursors, and fidelity checks of RNA quality. In turn, the assemblies modulate and guide the activities of the helicases. We describe the roles of RNA helicases with a conserved "DExD/H box" sequence motif in representative examples of such machineries from bacteria, archaea and eukaryotes. The recurrent occurrence of such helicases in complex assemblies throughout the course of evolution suggests a common requirement for their activities to meet cellular demands for the dynamic control of RNA metabolism.

Indexed as

RNA StabilityAnimalsBacteriaDNA HelicasesEnzyme ActivationExoribonucleasesExosomesGene Expression RegulationHumansPolyribonucleotide NucleotidyltransferaseProtein BindingRNARNA HelicasesRNA, MessengerDNA HelicasesExoribonucleasesPolyribonucleotide NucleotidyltransferaseRNARNA HelicasesRNA, MessengerDExD/H box helicaseexosomenon-coding RNApost-transcriptional regulationribonucleaseRNA degradosomeRNA helicaseRNA-protein interactionsRNA surveillanceRNA turnover

Identifiers

PMID23064154
PMCPMC3590238
OpenAlexW1994343117

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.