ReviewBrain research2013
Pharmacosynthetics: Reimagining the pharmacogenetic approach.
Review in Brain research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed.
- Off-target effects of DREADD ligands revealed by an anesthesia emergence paradigm in mice.Cell reports methods · 2026Article
- Regulating astrocytic activity in the dorsal striatum mitigates L-dopa-induced dyskinesia in Parkinson's disease.Scientific reports · 2025Article
- Adolescent Cerebellar Nuclei Manipulation Alters Reversal Learning and Perineuronal Net Intensity Independently in Male and Female Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Rapid injection of lumbar dorsal root ganglia under direct vision: Relevant anatomy, protocol, and behaviors.Frontiers in neurology · 2023Article
- An entorhinal-visual cortical circuit regulates depression-like behaviors.Molecular psychiatry · 2022Article
- Chimeric GPCRs mimic distinct signaling pathways and modulate microglia responses.Nature communications · 2022Article
- Review
- Characterization of DREADD receptor expression and function in rhesus macaques trained to discriminate ethanol.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- DREADDs in Epilepsy Research: Network-Based Review.Frontiers in molecular neuroscience · 2022Review
- Chemogenetics drives paradigm change in the investigation of behavioral circuits and neural mechanisms underlying drug action.Behavioural brain research · 2021Review
- Neurotransmitters, Cell Types, and Circuit Mechanisms of Motor Skill Learning and Clinical Applications.Frontiers in neurology · 2021Review
- A Neural Circuit from Thalamic Paraventricular Nucleus to Central Amygdala for the Facilitation of Neuropathic Pain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys.Nature neuroscience · 2020Article
- Dynamic Representation of Taste-Related Decisions in the Gustatory Insular Cortex of Mice.Current biology : CB · 2020Article
- Chemogenetic Stimulation and Silencing of the Insula, Amygdala, Nucleus Accumbens, and Their Connections Differentially Modulate Alcohol Drinking in Rats.Frontiers in behavioral neuroscience · 2020Article
- Optogenetics: Therapeutic spark in neuropathic pain.Bosnian journal of basic medical sciences · 2019Review
- Alcohol withdrawal drives depressive behaviors by activating neurons in the rostromedial tegmental nucleus.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- The use of chemogenetic approaches in alcohol use disorder research and treatment.Alcohol (Fayetteville, N.Y.) · 2019Review
- A Comparative Study of the Pharmacokinetics of ClozapineThe Journal of pharmacology and experimental therapeutics · 2019Article
- The use of chemogenetics in behavioural neuroscience: receptor variants, targeting approaches and caveats.British journal of pharmacology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Pharmacology, in its broadest interpretation, is defined as the study of the interaction between physiological entities and drugs. In modern neuropsychopharmacology, this interaction is viewed as the drug itself on one side and signal transducer (receptor), the signal transduction cascade (effector proteins, second messengers), the cellular response (transcriptional regulation, activity modulation), the organ response (brain circuitry modulation), and, finally, the whole organism response (behavior) on the other. In other words, pharmacology has structured itself around the idea that the exogenous molecule (the drug) encodes a "signal" leading to everything on the other side including, in extreme renditions, a physiological response. The inference is that engaging a particular signal transduction pathway in a defined cell type leads inexorably to a prototypic physiological response. Thus, for instance, serotonergic activation of 5-HT(2A) receptors in rat aortic smooth muscle cells leads to an increase in intracellular Ca(++) (via IP₃ release) and smooth muscle contraction (Roth et al., 1986). Here, we suggest that the invention of synthetic ligand--GPCR pairs (aka DREADDs, RASSLS, 'pharmacogenetics') permits the study of pharmacology using a shifted equation: more of the signal transduction elements moved to the left and, subsequently, under experimental control. For the purposes of disambiguation and to clarify this new interpretation as a creation of pharmacological manipulation, we present the term pharmacosynthetics to describe what has heretofore been called pharmacogenetics or chemicogenetics. This review discusses this new interpretation and reviews recent applications of the technology and considerations of the approach. This article is part of a Special Issue entitled Optogenetics (7th BRES).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.