ArticleBone2013
The role of oxygen during fracture healing.
Article in Bone, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed, 121 citations in OpenAlex.
- Clinical Assessment of the Hyperbaric Oxygen Therapy Efficacy in Mild to Moderate Periodontal Affections: A Simple Randomised Trial.Medicina (Kaunas, Lithuania) · 2022Trial
- Ultrasound-triggered release of an active Wnt signalling agent (6-bromoindirubin-3-oxime) from perfluorocarbon nanodroplets.RSC pharmaceutics · 2026Article
- The Role of Endothelial Dysfunction in Fracture Healing: Mechanisms and Potential Effects on Skeletal Repair.International journal of molecular sciences · 2026Review
- Oxygen‑sensing histone demethylase KDM6A modulates chondrocyte‑to‑osteoblast transdifferentiation by activating the Wnt/β‑catenin pathway.International journal of molecular medicine · 2026Article
- Tri-modal nanocatalytic microenvironment regulations for macrophage reprogramming and osteoporotic fracture healing promotion.Materials today. Bio · 2026Article
- Sustained Decrease in Oxygen Saturation in Human Fibular Fractures Monitored with Laser-Doppler and White-Light Spectroscopy: A Longitudinal Observational Pilot Study.Journal of functional biomaterials · 2026Article
- Perfluorocarbon nanodroplets are cytocompatible with osteoblast-lineage cells and modulate in vitro osteoclastogenesis differentially in normoxia and hypoxia.Scientific reports · 2026Article
- The Use of Recombinant Bone Morphogenetic Protein-2 in the Treatment of Spondylodiscitis.Global spine journal · 2026Article
- Computational models for predicting bone fracture healing: a review of modeling approaches, predictions, and emerging strategies.Biomechanics and modeling in mechanobiology · 2026Review
- A spatiotemporal atlas of senescence-associated secretory phenotype in fracture healing: stage-dependent mechanisms and therapeutic windows.Inflammation and regeneration · 2026Review
- When broken bones need air: Erythrocytes step in to heal.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Erythroid precursors regulate local oxygen tension and repair outcomes in the bone marrow niche.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Evaluation of a Gel Loaded With M101 on Bone and Peri-Implantitis Healing: An Experimental In Vivo Study.Clinical oral implants research · 2025Article
- Modulation of primary human apical papilla stem cells: Influence of Enterococcus faecalis, oxygen levels, and calcium silicate-based cements.European journal of oral sciences · 2025Article
- Erythroid precursors regulate local oxygen tension and repair outcomes in the bone marrow niche.bioRxiv : the preprint server for biology · 2025Article
- Nicotine, tobacco smoking, and pain in orthopedic trauma settings: a conceptual framework for practice and research.Archives of orthopaedic and trauma surgery · 2025Review
- Integrating spatial and single-cell transcriptomics to characterize mouse long bone fracture healing process.Communications biology · 2025Article
- Healing of Extensive Through-and-Through Periradicular Lesion Using Apicoectomy Without Bone Grafting: A Case Report With 3-Year Recall.Case reports in dentistry · 2025Article
- A computational model that integrates unrestricted callus growth, mechanobiology, and angiogenesis can predict bone healing in rodents.Scientific reports · 2024Article
- Fabricating oxygen self-supplying 3D printed bioactive hydrogel scaffold for augmented vascularized bone regeneration.Bioactive materials · 2024Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
Oxygen affects the activity of multiple skeletogenic cells and is involved in many processes that are important for fracture healing. However, the role of oxygen in fracture healing has not been fully studied. Here we systematically examine the effects of oxygen tension on fracture healing and test the ability of hyperoxia to rescue healing defects in a mouse model of ischemic fracture healing. Mice with tibia fracture were housed in custom-built gas chambers and groups breathed a constant atmosphere of 13% oxygen (hypoxia), 21% oxygen (normoxia), or 50% oxygen (hyperoxia). The influx of inflammatory cells to the fracture site, stem cell differentiation, tissue vascularization, and fracture healing were analyzed. In addition, the efficacy of hyperoxia (50% oxygen) as a treatment regimen for fracture nonunion was tested. Hypoxic animals had decreased tissue vascularity, decreased bone formation, and delayed callus remodeling. Hyperoxia increased tissue vascularization, altered fracture healing in un-complicated fractures, and improved bone repair in ischemia-induced delayed fracture union. However, neither hypoxia nor hyperoxia significantly altered chondrogenesis or osteogenesis during early stages of fracture healing, and infiltration of macrophages and neutrophils was not affected by environmental oxygen after bone injury. In conclusion, our results indicate that environmental oxygen levels affect tissue vascularization and fracture healing, and that providing oxygen when fractures are accompanied by ischemia may be beneficial.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.