ArticleGynecologic oncology2013
Non-steroidal anti-inflammatory drugs and endometrial cancer risk in the VITamins And Lifestyle (VITAL) cohort.
Article in Gynecologic oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Associations between aspirin use and the risk of cancers: a meta-analysis of observational studies.BMC cancer · 2018Pooled it
- The Role and Regulation of Thromboxane AMolecules (Basel, Switzerland) · 2022Review
- Analgesic Use and Circulating Estrogens, Androgens, and Their Metabolites in the Women's Health Initiative Observational Study.Cancer prevention research (Philadelphia, Pa.) · 2022Observational
- Aspirin associated with a decreased incidence of uterine cancer: A retrospective population-based cohort study.Medicine · 2020Observational
- COX-2-PGEArchives of gynecology and obstetrics · 2020Review
- Aspirin use and endometrial cancer risk: a meta-analysis and systematic review.Annals of translational medicine · 2020Article
- Use of aspirin, other nonsteroidal anti-inflammatory drugs and acetaminophen and risk of endometrial cancer: the Epidemiology of Endometrial Cancer Consortium.Annals of oncology : official journal of the European Society for Medical Oncology · 2019Article
- Role of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) in Cancer Prevention and Cancer Promotion.Advances in pharmacological sciences · 2019Review
- Review
- Glucosamine use and risk of colorectal cancer: results from the Cancer Prevention Study II Nutrition Cohort.Cancer causes & control : CCC · 2018Article
- Aspirin use and endometrial cancer risk and survival.Gynecologic oncology · 2018Review
- Nonsteroidal Anti-inflammatory Drugs and Endometrial Carcinoma Mortality and Recurrence.Journal of the National Cancer Institute · 2017Article
- Response to comment from Brasky et al.Gynecologic oncology reports · 2016Article
- Prostaglandin E2 (PGE2) promotes proliferation and invasion by enhancing SUMO-1 activity via EP4 receptor in endometrial cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Aspirin and endometrial cancer risk.Gynecologic oncology reports · 2016Article
- Associations of Dietary Long-Chain ω-3 Polyunsaturated Fatty Acids and Fish Consumption With Endometrial Cancer Risk in the Black Women's Health Study.American journal of epidemiology · 2016Article
- PTEN expression in benign human endometrial tissue and cancer in relation to endometrial cancer risk factors.Cancer causes & control : CCC · 2015Article
- Risk of Endometrial Cancer in Women With Pelvic Inflammatory Disease: A Nationwide Population-Based Retrospective Cohort Study.Medicine · 2015Article
- Long-chain ω-3 fatty acid intake and endometrial cancer risk in the Women's Health Initiative.The American journal of clinical nutrition · 2015Article
- Associations of long-chain ω-3 fatty acids and fish intake with endometrial cancer risk in the VITamins And Lifestyle cohort.The American journal of clinical nutrition · 2014Observational
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveChronic inflammation may be an important factor in the initiation and promotion of endometrial cancer. Use of non-steroidal anti-inflammatory drugs (NSAIDs), however, has been inconsistently associated with endometrial cancer risk.
methods22,268 female residents of western Washington State, ages 50-76, completed a baseline questionnaire in 2000-2002 and reported on their use of individual NSAIDs over the past 10years. Use was categorized as none, low (<4days/week or <4years), and high (≥4days/week and ≥4years). Over 9years of follow-up, 262 incident invasive endometrial cancers were identified. Multivariable proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI).
resultsRelative to non-use, high use of aspirin was inversely associated with endometrial cancer risk (HR 0.64, 95% CI: 0.41-1.01; P trend=0.03). Findings were stronger for regular-strength than low-dose aspirin. High use of non-aspirin NSAIDs (HR 1.15, 95% CI: 0.68-1.95), including ibuprofen (HR 1.29, 95% CI: 0.73-2.28), and naproxen (HR 1.08, 95% CI: 0.39-2.95) was not associated with risk. In subgroup analyses, findings for aspirin were strongest for cancers of endometrioid histology and were restricted to non-smokers.
conclusionsThis study provides additional evidence that use of aspirin, but not non-aspirin NSAIDs, may reduce the risk of endometrial cancer, especially in estrogen-mediated cases; however additional prospective studies with high-quality measurement of NSAID use are needed. Aspirin should continue to be examined as a potential agent for cancer chemoprevention.
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