ArticleNeuroImage2013
Variation in longitudinal trajectories of regional brain volumes of healthy men and women (ages 10 to 85 years) measured with atlas-based parcellation of MRI.
Article in NeuroImage, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 145 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
145 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Distinct brain structural abnormalities in attention-deficit/hyperactivity disorder and substance use disorders: A comparative meta-analysis.Translational psychiatry · 2022Pooled it
- Neurobiological and Cognitive Profile of Young Binge Drinkers: a Systematic Review and Meta-Analysis.Neuropsychology review · 2019Pooled it
- Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume.Nature communications · 2018Pooled it
- A meta-analysis of sex differences in human brain structure.Neuroscience and biobehavioral reviews · 2014Pooled it
- A comparative evaluation of brain MRI modalities, modality-specific measures, brain regions, and cognitive tests for brain age prediction.GeroScience · 2026Article
- Joint trajectories of brain atrophy, white matter hyperintensities and cognition quantify brain maintenance.Nature communications · 2026Article
- Sexual Dimorphisms in Neurodevelopment May Affect TBI Recovery in Pediatric Patients.Biomedicines · 2025Review
- In vivo growth trajectories of regional brain volumes in the Wistar rat.Neurobiology of aging · 2025Article
- Regional brain aging patterns reveal disease-specific pathways of neurodegeneration.medRxiv : the preprint server for health sciences · 2025Article
- Longitudinal non-linear changes in the microstructure of the hippocampal subfields in older adults.Neurobiology of aging · 2025Article
- The association between rapid antiretroviral therapy initiation and brain structure and function based on multimodal magnetic resonance imaging in HIV-positive men who have sex with men.BMC infectious diseases · 2025Article
- Healthy Cognitive Aging Through Movement: A Practical Approach of Light-Intensity Aerobic Dance for Older Adults.Advances in neurobiology · 2025Review
- Understanding Cognitive Decline in Aging: Mechanisms and Mitigation Strategies - A Narrative Review.Clinical interventions in aging · 2025Review
- Changes in voxel-wise gray matter asymmetry over time.Frontiers in neuroscience · 2025Article
- A review of applications of automated ventricular parcellation from magnetic resonance imaging of the brain.Frontiers in neurology · 2025Review
- Biological Sex Disparities in Alzheimer's Disease.Current topics in behavioral neurosciences · 2025Review
- Investigating dynamic brain functional redundancy as a mechanism of cognitive reserve.Frontiers in aging neuroscience · 2025Article
- Article
- Reduced brain network segregation in alcohol use disorder: Associations with neurocognition.Addiction biology · 2024Article
- A longitudinal study of the relationship between alcohol-related blackouts and attenuated structural brain development.Developmental cognitive neuroscience · 2024Article
85 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Numerous cross-sectional MRI studies have characterized age-related differences in regional brain volumes that differ with structure and tissue type. The extent to which cross-sectional assumptions about change are accurate depictions of actual longitudinal measurement remains controversial. Even longitudinal studies can be limited by the age range of participants, sex distribution of the samples, and scan intervals. To address these issues, we calculated trajectories of regional brain volume changes from T1-weighted (SPGR) MRI data, quantified with our automated, unsupervised SRI24 atlas-based registration and parcellation method. Longitudinal MRIs were acquired at 3T in 17 boys and 12 girls, age 10 to 14 years, and 41 men and 41 women, age 20 to 85 years at first scan. Application of a regression-based correction function permitted merging of data acquired at 3T field strength with data acquired at 1.5T from additional subjects, thereby expanding the sample to a total of 55 men and 67 women, age 20 to 85 years at first scan. Adjustment for individual supratentorial volume removed regional volume differences between men and women due to sex-related differences in head size. Individual trajectories were computed from data collected on 2 to 6 MRIs at a single field strength over a ~1 to 8 year interval. Using linear mixed-effects models, the pattern of trajectories over age indicated: rises in ventricular and Sylvian fissure volumes, with older individuals showing faster increases than younger ones; declines in selective cortical volumes with faster tissue shrinkage in older than younger individuals; little effect of aging on volume of the corpus callosum; more rapid expansion of CSF-filled spaces in men than women after age 60 years; and evidence for continued growth in central white matter through early adulthood with accelerated decline in senescence greater in men than women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.