ArticleCurrent biology : CB2012
Identical genomic organization of two hemichordate hox clusters.
Article in Current biology : CB, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 49 citations in OpenAlex.
- Sea CucumberResearch square · 2026Article
- Comparative transcriptomics reveal the common anteroposterior molecular blueprint of adult bilaterian guts.PLoS biology · 2026Article
- Expression of HOX Cluster Genes in Early Larval Development of Sea Urchin Strongylocentrotus intermedius (Echinodermata, Echinoidea).Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2025Article
- The brittle star genome illuminates the genetic basis of animal appendage regeneration.Nature ecology & evolution · 2024Article
- Seeking Sense in the Hox Gene Cluster.Journal of developmental biology · 2022Review
- Illusional Perspective across Humans and Bees.Vision (Basel, Switzerland) · 2022Review
- Structural and evolutionary insights into astacin metallopeptidases.Frontiers in molecular biosciences · 2022Article
- The Degenerate Tale of Ascidian Tails.Integrative and comparative biology · 2021Review
- Genomic insights of body plan transitions from bilateral to pentameral symmetry in Echinoderms.Communications biology · 2020Article
- I-SceI Meganuclease-mediated transgenesis in the acorn worm, Saccoglossus kowalevskii.Developmental biology · 2019Article
- Two more Posterior Hox genes and Hox cluster dispersal in echinoderms.BMC evolutionary biology · 2018Article
- The phylum Vertebrata: a case for zoological recognition.Zoological letters · 2018Review
- Hox gene cluster of the ascidian,Zoological letters · 2017Article
- HOXs and lincRNAs: Two sides of the same coin.Science advances · 2016Review
- Hemichordate genomes and deuterostome origins.Nature · 2015Article
- Nodal signaling is required for mesodermal and ventral but not for dorsal fates in the indirect developing hemichordate, Ptychodera flava.Biology open · 2015Article
- The deuterostome context of chordate origins.Nature · 2015Review
- On a possible evolutionary link of the stomochord of hemichordates to pharyngeal organs of chordates.Genesis (New York, N.Y. : 2000) · 2014Review
- Article
- Evolution of Hox gene clusters in deuterostomes.BMC developmental biology · 2013Review
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Authors and funding
18 authors at 11 institutions in 2 countries.
Funding
Abstract
Genomic comparisons of chordates, hemichordates, and echinoderms can inform hypotheses for the evolution of these strikingly different phyla from the last common deuterostome ancestor. Because hox genes play pivotal developmental roles in bilaterian animals, we analyzed the Hox complexes of two hemichordate genomes. We find that Saccoglossus kowalevskii and Ptychodera flava both possess 12-gene clusters, with mir10 between hox4 and hox5, in 550 kb and 452 kb intervals, respectively. Genes hox1-hox9/10 of the clusters are in the same genomic order and transcriptional orientation as their orthologs in chordates, with hox1 at the 3' end of the cluster. At the 5' end, each cluster contains three posterior genes specific to Ambulacraria (the hemichordate-echinoderm clade), two forming an inverted terminal pair. In contrast, the echinoderm Strongylocentrotus purpuratus contains a 588 kb cluster of 11 orthologs of the hemichordate genes, ordered differently, plausibly reflecting rearrangements of an ancestral hemichordate-like ambulacrarian cluster. Hox clusters of vertebrates and the basal chordate amphioxus have similar organization to the hemichordate cluster, but with different posterior genes. These results provide genomic evidence for a well-ordered complex in the deuterostome ancestor for the hox1-hox9/10 region, with the number and kind of posterior genes still to be elucidated.
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