ArticleBioorganic & medicinal chemistry letters2012
Glycan array analysis of the antigen repertoire targeted by tumor-binding antibodies.
Article in Bioorganic & medicinal chemistry letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- A Tumor-Selective Monoclonal Antibody from Immunization with a Tumor-Associated Mucin Glycopeptide.Scientific reports · 2019Article
- Shotgun Glycomics Identifies Tumor-Associated Glycan Ligands Bound by an Ovarian Carcinoma-Specific Monoclonal Antibody.Scientific reports · 2017Article
- The Glycan Array Platform as a Tool to Identify Carbohydrate Antigens.Methods in molecular biology (Clifton, N.J.) · 2015Article
- Are glycan biosensors an alternative to glycan microarrays?Analytical methods : advancing methods and applications · 2014Article
- Importance of N-glycosylation on CD147 for its biological functions.International journal of molecular sciences · 2014Review
- A vision for vaccines built from fully synthetic tumor-associated antigens: from the laboratory to the clinic.Journal of the American Chemical Society · 2013Article
- Glycoprotein disease markers and single protein-omics.Molecular & cellular proteomics : MCP · 2013Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Immunization with whole cells has been used extensively to generate monoclonal antibodies, produce protective immune responses, and discover new disease antigens. While glycans are abundant on cell surfaces, anti-glycan immune responses have not been well-characterized. We used glycan microarrays to profile 49 tumor-binding monoclonal antibodies generated by immunizing mice with whole cancer cells. A substantial proportion (41%) of the tumor binding antibodies bound carbohydrate antigens. The antibodies primarily recognize a group of 5 glycan antigens: Sialyl Lewis A (SLeA), Lewis A (LeA), Lewis X (LeX), blood group A (BG-A), and blood group H on a type 2 chain (BG-H2). The results have important implications for monoclonal antibody production and cancer vaccine development.
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Registered trials
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