ArticleCell2012
The problem with mixing mitochondria.
Article in Cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 45 citations in OpenAlex.
- Optimal Organelle Inheritance Strategies Under Different Changing Environments and Mutational Pressures.Genome biology and evolution · 2026Article
- Article
- Evolution and maintenance of mtDNA gene content across eukaryotes.The Biochemical journal · 2024Review
- Operation "mitochondrial wipeout" - clearing recipient mitochondria DNA during the cytoplasmic replacement therapy.Journal of assisted reproduction and genetics · 2022Article
- Heteroplasmy of Wild-Type Mitochondrial DNA Variants in Mice Causes Metabolic Heart Disease With Pulmonary Hypertension and Frailty.Circulation · 2022Article
- Lack of transcriptional coordination between mitochondrial and nuclear oxidative phosphorylation genes in the presence of two divergent mitochondrial genomes.Zoological research · 2022Article
- Organelle bottlenecks facilitate evolvability by traversing heteroplasmic fitness valleys.Frontiers in genetics · 2022Article
- A Naturally Heteroplasmic Clam Provides Clues about the Effects of Genetic Bottleneck on Paternal mtDNA.Genome biology and evolution · 2021Article
- The Pheromone and Pheromone Receptor Mating-Type Locus Is Involved in Controlling Uniparental Mitochondrial Inheritance inGenetics · 2020Article
- Linking the mitochondrial genotype to phenotype: a complex endeavour.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Evolving mtDNA populations within cells.Biochemical Society transactions · 2019Review
- Development of the MitoQ assay as a real-time quantification of mitochondrial DNA in degraded samples.International journal of legal medicine · 2019Article
- Metabolic remodelling associated with mtDNA: insights into the adaptive value of doubly uniparental inheritance of mitochondria.Proceedings. Biological sciences · 2019Article
- Population level mitogenomics of long-lived bats reveals dynamic heteroplasmy and challenges the Free Radical Theory of Ageing.Scientific reports · 2018Article
- Large-scale genetic analysis reveals mammalian mtDNA heteroplasmy dynamics and variance increase through lifetimes and generations.Nature communications · 2018Article
- Article
- Incompatibility between Nuclear and Mitochondrial Genomes Contributes to an Interspecies Reproductive Barrier.Cell metabolism · 2016Article
- Article
- Mitonuclear Ecology.Molecular biology and evolution · 2015Review
- Selection against heteroplasmy explains the evolution of uniparental inheritance of mitochondria.PLoS genetics · 2015Article
Corrections and comments
- Comment on
- Erratum issued
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mixing of mitochondrial DNAs (heteroplasmy) is unfavorable for reasons unknown. Sharpley et al. show that heteroplasmy has surprising genetic and behavioral effects in mice, even when each haplotype alone produces a normal phenotype. This interference is bioenergetic and may have contributed to the evolution of sexes.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.