ArticleOral oncology2013
Molecular etiology of second primary tumors in contralateral tonsils of human papillomavirus-associated index tonsillar carcinomas.
Article in Oral oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Association between tonsillectomy and oropharyngeal cancer risk: a retrospective cohort study.Oral and maxillofacial surgery · 2024Article
- Incidence of synchronous contralateral tonsillar malignancy in a known case of unilateral tonsillar carcinoma.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022Article
- Prevalence of Transcriptionally Active HPV Infection in Tumor-Free Oropharyngeal Tissue of OPSCC-Patients.Frontiers in oncology · 2022Article
- Current Status of Human Papillomavirus-Related Head and Neck Cancer: From Viral Genome to Patient Care.Virologica Sinica · 2021Review
- Exploring the roles of HPV16 variants in head and neck squamous cell carcinoma: current challenges and opportunities.Virology journal · 2021Review
- Article
- Two for the price of one: Prevalence, demographics and treatment implications of multiple HPV mediated Head and Neck Cancers.Oral oncology · 2020Article
- Viral Integration Analysis Reveals Likely Common Clonal Origin of Bilateral HPV16-Positive, p16-Positive Tonsil Tumors.Archives of clinical and medical case reports · 2020Article
- Targeting minimal residual disease: a path to cure?Nature reviews. Cancer · 2018Review
- Synchronous HPV-Related Cancer of Bilateral Tonsils Detected Using Transoral Endoscopic Examination with Narrow-Band Imaging.Case reports in otolaryngology · 2017Article
- Synchronous bilateral tonsil carcinoma: case presentation and review of the literature.Infectious agents and cancer · 2017Review
- Severe prolonged dysphagia following transoral resection of bilateral synchronous tonsillar carcinoma.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2015Article
- Metachronous Second Primary Malignancies after Head and Neck Cancer in a Korean Cohort (1993-2010).PloS one · 2015Article
- Surgically treated oropharyngeal cancer: risk factors and tumor characteristics.Journal of cancer research and clinical oncology · 2014Article
- Human Papillomavirus-associated oropharyngeal cancer: an observational study of diagnosis, prevalence and prognosis in a UK population.BMC cancer · 2013Observational
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
objectivesFor patients with tobacco-related head and neck squamous cell carcinoma (HNSCC), the occurrence of a second primary tumor (SPT) is an ominous development that is attributed to a field cancerization effect and portends a poor clinical outcome. The goal of this study was to determine whether patients with human papillomavirus (HPV)-related index tonsillar carcinomas can also develop SPTs in the contralateral tonsil, and to discern the molecular etiology of HPV-related tumor multifocality. MATERIALS AND
methodsThe surgical pathology archives of The Johns Hopkins Hospital were searched for all patients with primary HPV-related tonsillar squamous cell carcinoma who developed a synchronous or metachronous carcinoma in the contralateral tonsil. The HPV-16 E6 exon was sequenced from each independent cancer site to determine whether the tumor pairs harbored the same or a different HPV-16 variant.
resultsFour patients with bilateral HPV-related tonsillar carcinomas were identified. In every case, the HPV DNA sequences derived from the index tumor and corresponding SPT were 100% concordant, indicating that the index and SPTs were caused by the same HPV-16 variant.
conclusionFor the small subset of patients with tonsillar carcinomas who develop SPTs in the contralateral tonsil, the index case and the SPT consistently harbored the same HPV variant. This finding suggests that HPV-related tumor multi-focality can be attributed either to independent inoculation events by the same virus, or by migration of HPV-infected cells from a single inoculation site to other regions of Waldeyer's ring.
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