ArticleDrug and alcohol dependence2013
Sex differences in disinhibition and its relationship to physical abuse in a sample of stimulant-dependent patients.
Article in Drug and alcohol dependence, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- The effect of neuroimmune signalling on drug addiction.Frontiers in pharmacology · 2026Review
- Sex-specific dysregulation of the CXProgress in neuro-psychopharmacology & biological psychiatry · 2025Article
- Gender differences in ADHD and impulsivity among alcohol or alcohol- and cocaine-dependent patients.Frontiers in psychiatry · 2025Article
- Adverse childhood experiences are associated with at-risk drinking, cannabis and illicit drug use in females but not males: an Emergency Department study.The American journal of drug and alcohol abuse · 2020Article
- Methamphetamine use alters human plasma extracellular vesicles and their microRNA cargo: An exploratory study.Journal of extracellular vesicles · 2020Article
- Drinking Context-Specific Dose-Response Models of Intimate Partner Violence Among an Urban Emergency Department Sample.Journal of studies on alcohol and drugs · 2020Article
- A systematic scoping review of research on Black participants in the National Drug Abuse Treatment Clinical Trials Network.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2020Article
- Sex differences in guanfacine effects on stress-induced stroop performance in cocaine dependence.Drug and alcohol dependence · 2017Article
- Self-reported attentional and motor impulsivity are related to age at first methamphetamine use.Addictive behaviors · 2017Article
- Sex differences in the interacting roles of impulsivity and positive alcohol expectancy in problem drinking: A structural brain imaging study.NeuroImage. Clinical · 2017Article
- Adolescent Corticosterone and TrkB Pharmaco-Manipulations Sex-Dependently Impact Instrumental Reversal Learning Later in Life.Frontiers in behavioral neuroscience · 2017Article
- Article
- Sex differences in psychiatric comorbidity and plasma biomarkers for cocaine addiction in abstinent cocaine-addicted subjects in outpatient settings.Frontiers in psychiatry · 2015Article
- Genetic, psychosocial, and demographic factors associated with social disinhibition in Mexican-origin youth.Brain and behavior · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundResearch suggests that impulsivity is a vulnerability factor for developing stimulant dependence, that women develop dependence more quickly than men, and that physical abuse can increase impulsivity and may have greater adverse health consequences in women. This study sought to tie these findings together by evaluating: (1) sex differences in disinhibition prior to lifetime initiation of stimulant abuse and (2) the relationship between physical abuse and disinhibition in stimulant-dependent patients.
methodThe Frontal Systems Behavior Scale (FrSBe) is a reliable and valid self-report assessment of three neurobehavioral domains associated with frontal systems functioning (Apathy, Disinhibition, and Executive Dysfunction, summed for a Total), that assesses pre-morbid functioning and has a specific cutoff for defining clinically significant abnormalities. Six sites evaluating 12-step facilitation for stimulant abusers obtained the FrSBe from 118 methamphetamine- and/or cocaine-dependent participants. Lifetime physical abuse was measured by the Addiction Severity Index (ASI).
resultsThe proportion reporting clinically significant disinhibition was significantly higher in women (64.9%) than in men (45.0%, p=0.04), with no significant difference on the other FrSBe scales. Physical abuse in women, but not men, was associated with worse functioning, with physically abused, relative to non-abused, women having a significantly greater proportion with clinically significant disinhibition (p<0.01) and total neurobehavioral abnormalities (p<0.01).
conclusionThese findings suggest that women may have significantly greater disinhibition than men prior to lifetime initiation of stimulant abuse and that physical abuse in women is associated with greater disinhibition.
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