ReviewVirology2012
Computational tools for viral metagenomics and their application in clinical research.
Review in Virology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Analysis of the overall development trends and hotspots in the research field of the human gut virome.Virology journal · 2025Review
- Exploring viral diversity and metagenomics in livestock: insights into disease emergence and spillover risks in cattle.Veterinary research communications · 2024Review
- From Whole Genome Shotgun Sequencing to Viral Community Profiling: The ViromeScan Tool.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Computational Tools for the Analysis of Uncultivated Phage Genomes.Microbiology and molecular biology reviews : MMBR · 2022Review
- A Previously Undescribed Highly Prevalent Phage Identified in a Danish Enteric Virome Catalog.mSystems · 2021Article
- ITN-VIROINF: Understanding (Harmful) Virus-Host Interactions by Linking Virology and Bioinformatics.Viruses · 2021Article
- Characterization of a Novel Mitovirus of the Sand FlyViruses · 2020Article
- Enteric Virome and Carcinogenesis in the Gut.Digestive diseases and sciences · 2020Review
- Using noninvasive metagenomics to characterize viral communities from wildlife.Molecular ecology resources · 2019Article
- Overview of Virus Metagenomic Classification Methods and Their Biological Applications.Frontiers in microbiology · 2018Review
- Article
- Assessing Species Diversity Using Metavirome Data: Methods and Challenges.Computational and structural biotechnology journal · 2017Review
- Challenges in the analysis of viral metagenomes.Virus evolution · 2016Review
- ViromeScan: a new tool for metagenomic viral community profiling.BMC genomics · 2016Article
- Development and virucidal activity of a novel alcohol-based hand disinfectant supplemented with urea and citric acid.BMC infectious diseases · 2016Article
- Article
- GenSeed-HMM: A Tool for Progressive Assembly Using Profile HMMs as Seeds and its Application in Alpavirinae Viral Discovery from Metagenomic Data.Frontiers in microbiology · 2016Article
- Viral assemblage composition in Yellowstone acidic hot springs assessed by network analysis.The ISME journal · 2015Article
- Unbiased metagenomic sequencing complements specific routine diagnostic methods and increases chances to detect rare viral strains.Diagnostic microbiology and infectious disease · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There are 100 times more virions than eukaryotic cells in a healthy human body. The characterization of human-associated viral communities in a non-pathological state and the detection of viral pathogens in cases of infection are essential for medical care and epidemic surveillance. Viral metagenomics, the sequenced-based analysis of the complete collection of viral genomes directly isolated from an organism or an ecosystem, bypasses the "single-organism-level" point of view of clinical diagnostics and thus the need to isolate and culture the targeted organism. The first part of this review is dedicated to a presentation of past research in viral metagenomics with an emphasis on human-associated viral communities (eukaryotic viruses and bacteriophages). In the second part, we review more precisely the computational challenges posed by the analysis of viral metagenomes, and we illustrate the problem of sequences that do not have homologs in public databases and the possible approaches to characterize them.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.