ArticleJournal of the American College of Cardiology2012
Role of circulating osteogenic progenitor cells in calcific aortic stenosis.
Article in Journal of the American College of Cardiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT04557345 (Evaluation of the Inflammatory Response and Long-term Calcification in Post-operated Aortic Valve Replacement Patients.), which is not on this map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of the Inflammatory Response and Long-term Calcification in Post-operated Aortic Valve Replacement Patients.
Who cites it
36 citing papers in PubMed, 72 citations in OpenAlex.
- Dynamic Changes in Circulating Osteogenic Progenitor Cells Following TAVI: Implications for Vascular Remodeling-EPC and EPC-OCN Dynamics After TAVI.Journal of clinical medicine · 2026Article
- Reduced Circulating α-Klotho Levels Are Associated With Elevated Mortality and Arterial Calcifications of Aorta and Iliac Arteries.Journal of the American Heart Association · 2025Article
- Transcatheter Aortic Valve Durability: Focus on Structural Valve Deterioration.Journal of the American Heart Association · 2025Review
- Review
- Bioprosthetic Valve Deterioration: Accumulation of Circulating Proteins and Macrophages in the Valve Interstitium.JACC. Basic to translational science · 2023Article
- Circulating Progenitor Cells Are Associated With Bioprosthetic Aortic Valve Deterioration: A Preliminary Study.Journal of the American Heart Association · 2023Article
- Role of oxidative stress in calcific aortic valve disease and its therapeutic implications.Cardiovascular research · 2022Review
- AGEs/RAGE Promote Osteogenic Differentiation in Rat Bone Marrow-Derived Endothelial Progenitor Cells via MAPK Signaling.Journal of diabetes research · 2022Article
- Stem Cells to the Rescue: Development and Application of Cell-Based Therapy for Microvascular Repair.Cells · 2021Article
- Associations between bone mineral density in different measurement locations and coronary artery disease: a cross-sectional study.Archives of osteoporosis · 2021Article
- Article
- Article
- Osteogenic circulating endothelial progenitor cells are linked to electrocardiographic conduction abnormalities in rheumatic patients.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2019Article
- Adaptive immune cells in calcific aortic valve disease.American journal of physiology. Heart and circulatory physiology · 2019Review
- Cumulative Rheumatic Inflammation Modulates the Bone-Vascular Axis and Risk of Coronary Calcification.Journal of the American Heart Association · 2019Article
- Cardiovascular calcification: artificial intelligence and big data accelerate mechanistic discovery.Nature reviews. Cardiology · 2019Review
- Circulating Osteogenic Progenitor Cells in Mild, Moderate, and Severe Aortic Valve Stenosis.Mayo Clinic proceedings · 2019Article
- Comparison of Rapidly Proliferating, Multipotent Aortic Valve-Derived Stromal Cells and Valve Interstitial Cells in the Human Aortic Valve.Stem cells international · 2019Article
- Experimental Metabolic Syndrome Model Associated with Mechanical and Structural Degenerative Changes of the Aortic Valve.Scientific reports · 2018Article
- Current Strategies for the Manufacture of Small Size Tissue Engineering Vascular Grafts.Frontiers in bioengineering and biotechnology · 2018Review
Corrections and comments
- Commented on by
- Erratum issuedMcGregor, Ulrike [added]
Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
objectivesThe purpose of this study was to determine the role of circulating endothelial progenitor cells with osteoblastic phenotype (EPC-OCN) in human aortic valve calcification (AVC).
backgroundRecent evidence suggests that rather than passive mineralization, AVC is an active atherosclerotic process with an osteoblastic component resembling coronary calcification. We have recently identified circulating EPCs with osteogenic properties carrying both endothelial progenitor (CD34, KDR) and osteoblastic (osteocalcin [OCN]) cell surface markers.
methodsBlood samples from controls (n = 22) and patients with mild to moderate calcific aortic stenosis (mi-moAS, n = 17), severe calcific AS (sAS, n = 26), and both sAS and severe coronary artery disease (sCAD) (n = 33) were collected during diagnostic coronary angiography. By using flow cytometry, peripheral blood mononuclear cells were analyzed for CD34, KDR, and OCN. Resected normal and calcified aortic valves were analyzed histologically.
resultsPatients with mi-moAS and patients with sAS/sCAD had significantly less EPCs (CD34+/KDR+/OCN-) than controls. Patients with sAS showed significantly higher numbers of EPC-OCN (CD34+/KDR+/OCN+) than controls. In addition, the percentage of EPC costaining for OCN was higher in all disease groups compared with controls. A subgroup analysis of younger patients with bicuspid sAS showed a similar pattern of significantly lower EPCs but a high percentage of coexpression of OCN. Immunofluorescence showed colocalization of nuclear factor kappa-B and OCN in diseased and normal valves. CD34+/OCN+ cells were abundant in the endothelial and deeper cell layers of calcific aortic valve tissue but not in normal aortic valve tissue.
conclusionsCirculating EPC-OCN may play a significant role in the pathogenesis and as markers of prognostication of calcific AS.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.