ArticleAnalytica chimica acta2012
Simultaneous analysis of 28 urinary VOC metabolites using ultra high performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (UPLC-ESI/MSMS).
Article in Analytica chimica acta, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 151 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
151 citing papers in PubMed, 1 synthesis or guideline pooled it, 328 citations in OpenAlex.
- Effects of controlled, acute exposure to air pollutants on heart rate variability in humans: a meta-regression and methodological recommendations.BMC public health · 2026Pooled it
- Differences in exposure to toxic and/or carcinogenic volatile organic compounds between Black and White cigarette smokers.Journal of exposure science & environmental epidemiology · 2021Trial
- Urinary Cyanoethyl Mercapturic Acid, a Biomarker of the Smoke Toxicant Acrylonitrile, Clearly Distinguishes Smokers From Nonsmokers.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020Trial
- The Impact of Exclusive Use of Very Low Nicotine Cigarettes on Compensatory Smoking: An Inpatient Crossover Clinical Trial.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Trial
- Association of environmental xylene exposure with diabetic kidney disease: a cross-sectional analysis and multi-omics evaluation of immune microenvironment mechanisms.Renal failure · 2026Article
- Prenatal urinary BTEX metabolite levels and length of gestation: preliminary results from a metropolitan Detroit birth cohort.BMJ paediatrics open · 2026Article
- Associations between volatile organic compound mixtures and allostatic load: Evidence from the Green Heart Louisville Project.Environmental research · 2026Article
- Volatile Organic Compound Metabolites Are Found in the Urine of Breastfed Infants Whose Mothers Use Cannabis: The Lactation and Cannabis (LAC) Study.International journal of environmental research and public health · 2026Article
- Association of volatile organic compounds with serum lactate dehydrogenase levels in the general adults.International archives of occupational and environmental health · 2026Article
- A unified liquid chromatography-mass spectrometric approach combining targeted and untargeted analyses for community exposure profiling in wastewater.Environment international · 2026Article
- The associations between volatile organic compounds and bone loss around teeth among US adults.BMC public health · 2026Article
- Analysis of 18 mercapturic acids in urine samples from the German Environmental Specimen Bank-tackling the data gap in the human biomonitoring of VOCs in Europe.Journal of exposure science & environmental epidemiology · 2026Article
- Association Between Volatile Organic Compound Metabolites in Urine and Adult Lung Function: Evidence From NHANES 2011-2012.The clinical respiratory journal · 2026Article
- Effect of Cigarette Type and Smoking Behavior on Urinary Metabolite Levels of Tobacco-Associated Toxicants.Chemical research in toxicology · 2026Article
- Dietary Factors Drive Volatile Organic Compound Exposure and Modulate Its Impact on Multi-Dimensional Biological Aging.Food science & nutrition · 2026Article
- The impacts of long-term carbon disulfide exposure on glucose homeostasis and type 2 diabetes: a multifaceted gene-environment-lifestyle interaction study of Chinese adults.Journal of advanced research · 2026Article
- Associations of volatile organic compounds with cancer: A cross-sectional analysis of single and mixture exposures.The Journal of international medical research · 2026Article
- [Exposures to volatile organic compounds are positively correlated with risks of metabolic dysfunction-associated steatotic liver disease].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026Article
- Genotoxic exposures to volatile organic compounds in golden retrievers with and without multicentric lymphoma.Frontiers in veterinary science · 2026Article
- Exploring the association between volatile organic compound exposure and chronic kidney disease: evidence from explainable machine learning methods.Renal failure · 2025Article
91 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Volatile organic compounds (VOCs) are ubiquitous in the environment, originating from many different natural and anthropogenic sources, including tobacco smoke. Long-term exposure to certain VOCs may increase the risk for cancer, birth defects, and neurocognitive impairment. Therefore, VOC exposure is an area of significant public health concern. Urinary VOC metabolites are useful biomarkers for assessing VOC exposure because of non-invasiveness of sampling and longer physiological half-lives of urinary metabolites compared with VOCs in blood and breath. We developed a method using reversed-phase ultra high performance liquid chromatography (UPLC) coupled with electrospray ionization tandem mass spectrometry (ESI/MSMS) to simultaneously quantify 28 urinary VOC metabolites as biomarkers of exposure. We describe a method that monitors metabolites of acrolein, acrylamide, acrylonitrile, benzene, 1-bromopropane, 1,3-butadiene, carbon-disulfide, crotonaldehyde, cyanide, N,N-dimethylformamide, ethylbenzene, ethylene oxide, propylene oxide, styrene, tetrachloroethylene, toluene, trichloroethylene, vinyl chloride and xylene. The method is accurate (mean accuracy for spiked matrix ranged from 84 to 104%), sensitive (limit of detection ranged from 0.5 to 20 ng mL(-1)) and precise (the relative standard deviations ranged from 2.5 to 11%). We applied this method to urine samples collected from 1203 non-smokers and 347 smokers and demonstrated that smokers have significantly elevated levels of tobacco-related biomarkers compared to non-smokers. We found significant (p<0.0001) correlations between serum cotinine and most of the tobacco-related biomarkers measured. These findings confirm that this method can effectively quantify urinary VOC metabolites in a population exposed to volatile organics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.