ArticleThe American journal of medicine2012
Preoperative statin use and postoperative acute kidney injury.
Article in The American journal of medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 4 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Incidence and risk factors of acute kidney injury after abdominal surgery: a systematic review and meta-analysis.Annals of medicine · 2025Pooled it
- Perioperative statin therapy in cardiac surgery: a meta-analysis of randomized controlled trials.Critical care (London, England) · 2016Pooled it
- Incidence and associations of acute kidney injury after major abdominal surgery.Intensive care medicine · 2016Pooled it
- Rhabdomyolysis in bariatric surgery: a systematic review.Obesity surgery · 2013Pooled it
- Divergent Role of Statin Use and Intensity in Patients Undergoing Transcatheter Aortic Valve Replacement.Cardiorenal medicine · 2026Article
- Preexisting statin therapy is not associated with reduced acute kidney injury following cardiac surgery: a retrospective analysis.Frontiers in pharmacology · 2025Review
- Prognostic Biomarkers and AKI: Potential to Enhance the Identification of Post-Operative Patients at Risk of Loss of Renal Function.Research and reports in urology · 2024Review
- Epidemiology of surgery associated acute kidney injury (EPIS-AKI): a prospective international observational multi-center clinical study.Intensive care medicine · 2023Observational
- Effects of statins on the incidence and outcomes of acute kidney injury in critically ill patients: a systematic review and meta-analysis.Archives of medical science : AMS · 2023Review
- Long-Term Preoperative Atorvastatin or Rosuvastatin Use in Adult Patients before CABG Does Not Increase Incidence of Postoperative Acute Kidney Injury: A Propensity Score-Matched Analysis.Pathophysiology : the official journal of the International Society for Pathophysiology · 2022Article
- EPIdemiology of Surgery-Associated Acute Kidney Injury (EPIS-AKI): study protocol for a multicentre, observational trial.BMJ open · 2021Article
- Long-term outcomes of acute kidney injury and strategies for improved care.Nature reviews. Nephrology · 2020Review
- Perioperative Statin Use and Acute Kidney Injury in Patients Undergoing Partial Nephrectomy.Kidney cancer (Clifton, Va.) · 2018Article
- Evaluation of the Effect of Statins on Post-Surgical Patients with Acute Kidney Injury.Maedica · 2017Article
- Perioperative Acute Kidney Injury: Risk Factors and Predictive Strategies.Critical care clinics · 2017Review
- Reassessment of Acute Kidney Injury after Cardiac Surgery: A Retrospective Study.Internal medicine (Tokyo, Japan) · 2017Article
- Renal protection in cardiovascular surgery.F1000Research · 2016Review
- Postoperative renal dysfunction independently predicts late mortality in patients undergoing aortic reconstruction.Journal of vascular surgery · 2015Article
- Acute Kidney Injury in the Surgical Patient.Critical care clinics · 2015Review
- Association between preoperative statin use and acute kidney injury biomarkers in cardiac surgical procedures.The Annals of thoracic surgery · 2014Article
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Abstract
backgroundAcute kidney injury is a frequent postoperative complication that confers increased mortality, morbidity, and costs. The purpose of this study was to evaluate whether preoperative statin use is associated with a decreased risk of postoperative acute kidney injury.
methodsWe assembled a retrospective cohort of 98,939 patients who underwent a major open abdominal, cardiac, thoracic, or vascular procedure between 2000 and 2010. Statin users were pair-matched to nonusers on the basis of surgery type, baseline kidney function, days from admission until surgery, and propensity score based on demographics, comorbid conditions, and concomitant medications. Acute kidney injury was defined based on changes in serum creatinine measurements applying Acute Kidney Injury Network and Risk-Injury-Failure staging systems, and on the need for renal replacement therapy. Associations between statin use and acute kidney injury were estimated by conditional logistic regression.
resultsAcross various acute kidney injury definitions, statin use was consistently associated with a decreased risk: adjusted odds ratios (95% confidence intervals) varied from 0.74 (0.58-0.95) to 0.80 (0.71-0.90). Associations were similar among diabetics and nondiabetics, and across strata of baseline kidney function. The protective association of statins was most pronounced among patients undergoing vascular surgery and least among patients undergoing cardiac surgery.
conclusionsPreoperative statin use is associated with a decreased risk of postoperative acute kidney injury. Future randomized clinical trials are needed to determine causality.
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