ArticleDevelopment and psychopathology2012
Maternal separation with early weaning: a rodent model providing novel insights into neglect associated developmental deficits.
Article in Development and psychopathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 83 citations in OpenAlex.
- Traumatic life experiences during critical periods lead to diverse developmental trajectories.Cell reports. Medicine · 2026Article
- Precocial Weaning Influences Anxiety, Social and Maternal Care but Not Cognition in African Striped Mice, Rhabdomys dilectus chakae.Developmental psychobiology · 2026Article
- Microglial depletion prevents visual deficits and retinal ganglion cell loss induced by early life stress in adult animals.Scientific reports · 2025Article
- Activation of somatostatin neurons in the medial amygdala reverses long-term aggression and social deficits associated to early-life stress in male mice.Molecular psychiatry · 2025Article
- Genetic diversity shapes behavioral outcomes and reveals sex differences in mice exposed to early life stress.bioRxiv : the preprint server for biology · 2025Article
- Genetically diverse mice exhibit divergent domain-specific, sex-dependent behavioral outcomes following exposure to early life stress.PloS one · 2025Article
- Early-life prefrontal cortex inhibition and early-life stress lead to long-lasting behavioral, transcriptional, and physiological impairments.Molecular psychiatry · 2024Article
- Influence of Diet on Reproducible Corticosterone Levels in a Mouse Model of Maternal Separation with Early Weaning.Life (Basel, Switzerland) · 2024Article
- The adipose tissue keeps the score: priming of the adrenal-adipose tissue axis by early life stress predisposes women to obesity and cardiometabolic risk.Frontiers in endocrinology · 2024Review
- Lasting impact of postnatal maternal separation on the developing BNST: Lifelong socioemotional consequences.Neuropharmacology · 2023Review
- The estrous cycle modulates early-life adversity effects on mouse avoidance behavior through progesterone signaling.Nature communications · 2022Article
- Early life stress exacerbates obesity in adult female mice via mineralocorticoid receptor-dependent increases in adipocyte triglyceride and glycerol content.Life sciences · 2022Article
- Early Life Stress Alters Expression of Glucocorticoid Stress Response Genes and Trophic Factor Transcripts in the Rodent Basal Ganglia.International journal of molecular sciences · 2022Article
- Review
- Inhibition of adult neurogenesis reduces avoidance behavior in male, but not female, mice subjected to early life adversity.Neurobiology of stress · 2022Article
- Early Life Adversity and Neuropsychiatric Disease: Differential Outcomes and Translational Relevance of Rodent Models.Frontiers in systems neuroscience · 2022Review
- White matter abnormalities in theFrontiers in molecular neuroscience · 2022Article
- Multiomic biological approaches to the study of child abuse and neglect.Pharmacology, biochemistry, and behavior · 2021Review
- Epididymal Fat-Derived Sympathoexcitatory Signals Exacerbate Neurogenic Hypertension in Obese Male Mice Exposed to Early Life Stress.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Decomposing complex links between the childhood environment and brain structure in school-aged youth.Developmental cognitive neuroscience · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Child neglect is the most prevalent form of child maltreatment in the United States, and poses a serious public health concern. Children who survive such episodes go on to experience long-lasting psychological and behavioral problems, including higher rates of post-traumatic stress disorder symptoms, depression, alcohol and drug abuse, attention-deficit/hyperactivity disorder, and cognitive deficits. To date, most research into the causes of these life-long problems has focused on well-established targets such as stress responsive systems, including the hypothalamus-pituitary-adrenal axis. Using the maternal separation and early weaning model, we have attempted to provide comprehensive molecular profiling of a model of early-life neglect in an organism amenable to genomic manipulation: the mouse. In this article, we report new findings generated with this model using chromatin immunoprecipitation sequencing, diffuse tensor magnetic resonance imaging, and behavioral analyses. We also review the validity of the maternal separation and early weaning model, which reflects behavioral deficits observed in neglected humans including hyperactivity, anxiety, and attentional deficits. Finally, we summarize the molecular characterization of these animals, including RNA profiling and label-free proteomics, which highlight protein translation and myelination as novel pathways of interest.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.