ReviewDevelopment and psychopathology2012
Confluence of genes, environment, development, and behavior in a post Genome-Wide Association Study world.
Review in Development and psychopathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- Gene-environment interactions in the influence of maternal education on adolescent neurodevelopment using ABCD study.Science advances · 2024Article
- Association studies between chromosomal regions 1q21.3, 5q21.3, 14q21.2 and 17q21.31 and numbers of children in Poland.Scientific reports · 2022Article
- Enrichment analyses identify shared associations for 25 quantitative traits in over 600,000 individuals from seven diverse ancestries.American journal of human genetics · 2022Article
- Article
- Using a developmental perspective to examine the moderating effects of marriage on heavy episodic drinking in a young adult sample enriched for risk.Development and psychopathology · 2021Article
- Is population structure in the genetic biobank era irrelevant, a challenge, or an opportunity?Human genetics · 2020Review
- Indicators of mental disorders in UK Biobank-A comparison of approaches.International journal of methods in psychiatric research · 2019Article
- Advancing statistical analysis of ambulatory assessment data in the study of addictive behavior: A primer on three person-oriented techniques.Addictive behaviors · 2018Review
- Genetic associations with reflexive visual attention in infancy and childhood.Developmental science · 2017Article
- Differential sensitivity to the environment: contribution of cognitive biases and genes to psychological wellbeing.Molecular psychiatry · 2016Article
- Molecular genetic approaches to understanding the comorbidity of psychiatric disorders.Development and psychopathology · 2016Review
- Translational Epidemiologic Approaches to Understanding the Consequences of Early-Life Exposures.Behavior genetics · 2016Review
- Attentional biases to emotional stimuli: Key components of the RDoC constructs of sustained threat and loss.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2016Review
- Examining gene-environment interactions in comorbid depressive and disruptive behavior disorders using a Bayesian approach.Journal of psychiatric research · 2015Article
- Assessing the utility of intermediate phenotypes for genetic mapping of psychiatric disease.Trends in neurosciences · 2014Review
- In search of rare variants: preliminary results from whole genome sequencing of 1,325 individuals with psychophysiological endophenotypes.Psychophysiology · 2014Article
- Interactions Between Monoamine Oxidase A and Punitive Discipline in African American and Caucasian Men's Antisocial Behavior.Clinical psychological science : a journal of the Association for Psychological Science · 2014Article
- Is the gene-environment interaction paradigm relevant to genome-wide studies? The case of education and body mass index.Demography · 2014Article
- Trans-ethnic genome-wide association studies: advantages and challenges of mapping in diverse populations.Genome medicine · 2014Article
- Considering alternative explanations for the associations among childhood adversity, childhood abuse, and adult sexual orientation: reply to Bailey and Bailey (2013) and Rind (2013).Archives of sexual behavior · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
This article serves to outline a research paradigm to investigate main effects and interactions of genes, environment, and development on behavior and psychiatric illness. We provide a historical context for candidate gene studies and genome-wide association studies, including benefits, limitations, and expected payoffs. Using substance use and abuse as our driving example, we then turn to the importance of etiological psychological theory in guiding genetic, environmental, and developmental research, as well as the utility of refined phenotypic measures, such as endophenotypes, in the pursuit of etiological understanding and focused tests of genetic and environmental associations. Phenotypic measurement has received considerable attention in the history of psychology and is informed by psychometrics, whereas the environment remains relatively poorly measured and is often confounded with genetic effects (i.e., gene-environment correlation). Genetically informed designs, which are no longer limited to twin and adoption studies thanks to ever-cheaper genotyping, are required to understand environmental influences. Finally, we outline the vast amount of individual difference in structural genomic variation, most of which remains to be leveraged in genetic association tests. Although the genetic data can be massive and burdensome (tens of millions of variants per person), we argue that improved understanding of genomic structure and function will provide investigators with new tools to test specific a priori hypotheses derived from etiological psychological theory, much like current candidate gene research but with less confusion and more payoff than candidate gene research has to date.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.