ReviewDevelopment and psychopathology2012
Bringing a developmental perspective to anxiety genetics.
Review in Development and psychopathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- The Double-Edged Sword Effect of Empathic Concern on Mental Health and Behavioral Outcomes: The Mediating Role of Excessive Adaptation.Behavioral sciences (Basel, Switzerland) · 2025Article
- Impact of parenting styles on preschoolers' behaviors.World journal of clinical cases · 2024Article
- Spatiotemporal expression patterns of anxiety disorder-associated genes.Translational psychiatry · 2023Article
- Blood transcriptome analysis suggests an indirect molecular association of early life adversities and adult social anxiety disorder by immune-related signal transduction.Frontiers in psychiatry · 2023Article
- Convergent neural correlates of prenatal exposure to air pollution and behavioral phenotypes of risk for internalizing and externalizing problems: Potential biological and cognitive pathways.Neuroscience and biobehavioral reviews · 2022Review
- Emerging Evidence for Putative Neural Networks and Antecedents of Pediatric Anxiety in the Fetal, Neonatal, and Infant Periods.Biological psychiatry · 2021Review
- A major role for common genetic variation in anxiety disorders.Molecular psychiatry · 2020Article
- The experience of the self in Canadian youth living with anxiety: A qualitative study.PloS one · 2020Article
- Depression and Anxiety in Preschoolers: A Review of the Past 7 Years.Child and adolescent psychiatric clinics of North America · 2017Review
- Long-Term Outcomes of Youth Treated for an Anxiety Disorder: A Critical Review.Clinical child and family psychology review · 2017Review
- The Genetics of Stress-Related Disorders: PTSD, Depression, and Anxiety Disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Review
- Interaction of CD38 Variant and Chronic Interpersonal Stress Prospectively Predicts Social Anxiety and Depression Symptoms Over Six Years.Clinical psychological science : a journal of the Association for Psychological Science · 2016Article
- Cytokine gene variations associated with trait and state anxiety in oncology patients and their family caregivers.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2015Article
- Shared Genetic Factors of Anxiety and Depression Symptoms in a Brazilian Family-Based Cohort, the Baependi Heart Study.PloS one · 2015Article
- Empathy as a "risky strength": a multilevel examination of empathy and risk for internalizing disorders.Development and psychopathology · 2014Review
- Genetic moderation of child maltreatment effects on depression and internalizing symptoms by serotonin transporter linked polymorphic region (5-HTTLPR), brain-derived neurotrophic factor (BDNF), norepinephrine transporter (NET), and corticotropin releasing hormone receptor 1 (CRHR1) genes in African American children.Development and psychopathology · 2014Article
- The future of genomics for developmentalists.Development and psychopathology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Despite substantial recent advancements in psychiatric genetic research, progress in identifying the genetic basis of anxiety disorders has been limited. We review the candidate gene and genome-wide literatures in anxiety, which have made limited progress to date. We discuss several reasons for this hindered progress, including small samples sizes, heterogeneity, complicated comorbidity profiles, and blurred lines between normative and pathological anxiety. To address many of these challenges, we suggest a developmental, multivariate framework that can inform and enhance anxiety phenotypes for genetic research. We review the psychiatric and genetic epidemiological evidence that supports such a framework, including the early onset and chronic course of anxiety disorders, shared genetic risk factors among disorders both within and across time, and developmentally dynamic genetic influences. We propose three strategies for developmentally sensitive phenotyping: examination of early temperamental risk factors, use of latent factors to model underlying anxiety liability, and use of developmental trajectories as phenotypes. Expanding the range of phenotypic approaches will be important for advancing studies of the genetic architecture of anxiety disorders.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.