ArticleNutrition and cancer2012
Associations between intake of folate and related micronutrients with molecularly defined colorectal cancer risks in the Iowa Women's Health Study.
Article in Nutrition and cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 4 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Associations between nutritional factors and KRAS mutations in colorectal cancer: a systematic review.BMC cancer · 2020Pooled it
- A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.Scientific reports · 2015Pooled it
- Vitamin and multiple-vitamin supplement intake and incidence of colorectal cancer: a meta-analysis of cohort studies.Medical oncology (Northwood, London, England) · 2015Pooled it
- Pooled it
- Unique role of the prospective cohort incident-tumor biobank method in etiological research.Lancet regional health. Americas · 2026Review
- Folate intake and colorectal cancer risk according to genetic subtypes defined by targeted tumor sequencing.The American journal of clinical nutrition · 2024Article
- Interactions between folate metabolism-related nutrients and polymorphisms on colorectal cancer risk: a case-control study in the Basque country.European journal of nutrition · 2024Observational
- Article
- Association between nutrient intake related to the one-carbon metabolism and colorectal cancer risk: a case-control study in the Basque Country.European journal of nutrition · 2023Observational
- Scientific opinion on the tolerable upper intake level for folate.EFSA journal. European Food Safety Authority · 2023Article
- Healthy and unhealthy plant-based diets in relation to the incidence of colorectal cancer overall and by molecular subtypes.Clinical and translational medicine · 2022Article
- The Revised D-A-CH-Reference Values for the Intake of Vitamin BMolecular nutrition & food research · 2019Article
- Multivitamin, calcium and folic acid supplements and the risk of colorectal cancer in Lynch syndrome.International journal of epidemiology · 2016Article
- One-Carbon Metabolism and Colorectal Cancer: Potential Mechanisms of Chemoprevention.Current pharmacology reports · 2015Article
- Associations between Environmental Exposures and Incident Colorectal Cancer by ESR2 Protein Expression Level in a Population-Based Cohort of Older Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2015Article
- Associations between S-adenosylmethionine, S-adenosylhomocysteine, and colorectal adenoma risk are modified by sex.American journal of cancer research · 2015Article
- Dietary inflammatory index and risk of colorectal cancer in the Iowa Women's Health Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2014Article
- Somatic expression of ENRAGE is associated with obesity status among patients with clear cell renal cell carcinoma.Carcinogenesis · 2014Article
- Associations between cigarette smoking, hormone therapy, and folate intake with incident colorectal cancer by TP53 protein expression level in a population-based cohort of older women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2014Article
- Microsatellite instability and BRAF mutation testing in colorectal cancer prognostication.Journal of the National Cancer Institute · 2013Article
Corrections and comments
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Authors and funding
18 authors at 7 institutions in 1 country.
Funding
Abstract
Folate and related micronturients may affect colorectal cancer (CRC) risk, but the molecular mechanism(s) remain incompletely defined. We analyzed associations between dietary folate, vitamin B6, vitamin B12, and methionine with incident CRC, overall and by microsatellite instability (MSS/MSI-L or MSI-H), CpG island methylator phenotype (CIMP-negative or CIMP-positive), BRAF mutation (negative or positive), and KRAS mutation (negative or positive) status in the prospective, population-based Iowa Women's Health Study (IWHS; 55-69 years at baseline; n = 41,836). Intake estimates were obtained from baseline, self-reported food frequency questionnaires. Molecular marker data were obtained for 514 incident CRC cases. Folate intake was inversely associated with overall CRC risk in age-adjusted Cox regression models, whereas methionine intake was inversely associated with overall CRC risk in multivariable-adjusted models [relative risk (RR) = 0.81; 95% CI = 0.69-0.95; P trend = 0.001 and RR = 0.72; 95% CI = 0.54-0.96; P trend = 0.03 for highest vs. lowest quartiles, respectively]. None of the dietary exposures were associated with MSI, CIMP, BRAF, or KRAS defined CRC subtypes. These data provide minimal support for major effects from the examined micronutrients on overall or molecularly defined CRC risks in the IWHS cohort.
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