ArticlePaediatric and perinatal epidemiology2012
Trends in the use of antiepileptic drugs among pregnant women in the US, 2001-2007: a medication exposure in pregnancy risk evaluation program study.
Article in Paediatric and perinatal epidemiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Precision medicine in women with epilepsy: The challenge, systematic review, and future direction.Epilepsy & behavior : E&B · 2021Pooled it
- Pregnancy and Delivery Outcomes Following Benzodiazepine Exposure: A Systematic Review and Meta-analysis.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2020Pooled it
- Inadequate Folic Acid Intake Among Women Taking Antiepileptic Drugs During Pregnancy in Japan: A Cross-Sectional Study.Scientific reports · 2019Trial
- Development of cerebral lateralization in children exposed to fetal antiseizure medications: A prospective cohort study at age 6 years.Epilepsia · 2026Article
- The use of newer anti-seizure medicines in women with epilepsy in pregnancy: A case series.Epilepsy & behavior reports · 2025Article
- Prediction of lacosamide concentrations to support dose optimization during pregnancy.Epilepsia · 2025Observational
- Women's health in focus: Real-world data on valproate prescriptions during pregnancy - a cohort study in Catalonia (Spain).BMJ open · 2024Article
- Trends and patterns of antiseizure medication prescribing during pregnancy between 1995 and 2018 in the United Kingdom: A cohort study.BJOG : an international journal of obstetrics and gynaecology · 2024Article
- Patterns of antiseizure medication prescription in pregnancy and maternal complications in women with epilepsy: A retrospective study in Saudi Arabia.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2022Article
- Trends of Utilization of Antiseizure Medications Among Pregnant Women in Manitoba, Canada: A 20-Year Population-Based Study.Frontiers in pharmacology · 2022Article
- Perampanel and pregnancy.Epilepsia · 2021Article
- Perampanel during pregnancy: Description of four cases.Epilepsy & behavior reports · 2021Article
- Gene Environment Interactions in the Etiology of Neural Tube Defects.Frontiers in genetics · 2021Review
- Approaches to studying the genomic architecture of complex birth defects.Prenatal diagnosis · 2020Review
- Article
- Effects of periconceptional folate on cognition in children of women with epilepsy: NEAD study.Neurology · 2020Observational
- Risks of 23 specific malformations associated with prenatal exposure to 10 antiepileptic drugs.Neurology · 2019Article
- Metabolome-wide association study of anti-epileptic drug treatment during pregnancy.Toxicology and applied pharmacology · 2019Observational
- Article
- Chronic Pain Prevalence and Exposures during Pregnancy.Pain research & management · 2019Article
Corrections and comments
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Authors and funding
18 authors at 11 institutions in 2 countries.
Funding
Abstract
backgroundLittle is known about the extent of antiepileptic drug (AED) use in pregnancy, particularly for newer agents. Our objective was to assess whether AED use has increased among pregnant women in the US, 2001-2007.
methodsWe analysed data from the Medication Exposure in Pregnancy Risk Evaluation Program (MEPREP) database, 1 January 2001 to 31 December 2007. We identified liveborn deliveries among women, aged 15-45 years on delivery date, who were members of MEPREP health plans (n=585615 deliveries). Pregnancy exposure to AEDs, determined through outpatient pharmacy dispensing files. Older AEDs were available for clinical use before 1993; other agents were considered newer AEDs. Information on sociodemographic and medical/reproductive factors was obtained from linked birth certificate files. Maternal diagnoses were identified based on ICD-9 codes.
resultsPrevalence of AED use during pregnancy increased between 2001 (15.7 per 1000 deliveries) and 2007 (21.9 per 1000 deliveries), driven primarily by a fivefold increase in the use of newer AEDs. Thirteen per cent of AED-exposed deliveries involved a combination of two or more AEDs. Psychiatric disorders were the most prevalent diagnoses, followed by epileptic and pain disorders, among AED users regardless of AED type, year of conception or gestational period.
conclusionsAED use during pregnancy increased between 2001 and 2007, driven by a fivefold increase in the use of newer AEDs. Nearly one in eight AED-exposed deliveries involved the concomitant use of more than one AED. Additional investigations of the reproductive safety of newer AEDs may be needed.
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