ReviewChemical research in toxicology2013
Reactive metabolites in the biotransformation of molecules containing a furan ring.
Review in Chemical research in toxicology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
61 citing papers in PubMed, 197 citations in OpenAlex.
- Tunable Sulfenylnitrenes Enable Scaffold Hopping of Furans Into N-Heterocycles.Angewandte Chemie (International ed. in English) · 2026Article
- Synthesis of Furan and Benzene Derivatives Containing Unsaturated Substituents with Electron-Withdrawing Groups, and Analysis of Their Antimicrobial Activity.Molecules (Basel, Switzerland) · 2026Article
- In vitro formation kinetics of two 2,5-dimethylfuran phase-I metabolites: cis-3-hexene-2,5-dione and 5-methylfurfuryl alcohol.Archives of toxicology · 2026Article
- 2-Alkyl Furans Undergo Radiolytic Oxidative Protein Cross-Linking.Journal of the American Chemical Society · 2026Article
- Urinary volatile organic compounds as potential non-invasive markers for childhood obesity.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Acute Hypotensive Effects of 2-Acetylfuran and 5-Methylfurfural and Their Impact on Liver Mitochondrial Bioenergetics.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Protein covalent modification and hepatic cytotoxicity of atorvastatin resulting from its metabolic activation.Archives of toxicology · 2026Article
- Advances in Natural Products from Mangrove-Associated Fungi Along the Indian Ocean Coast.Molecules (Basel, Switzerland) · 2026Review
- Bis-Oxadiazole Assemblies as NO-Releasing Anticancer Agents.Pharmaceutics · 2025Article
- Profiling the Cellular Surfaceome by Furan-Based Protein Biotinylation.Journal of proteome research · 2025Article
- Chromatin Regulatory Targets for Anticancer Therapeutics.Chemical reviews · 2025Review
- Formation of the toxic furan metabolite 2-butene-1,4-dial through hemin-induced degradation of 2,4-alkadienals in fried foods.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2025Article
- Studies of Structure-Activity Relationship of 2-(Pyrrolidin-1ylmethyl)-1ACS medicinal chemistry letters · 2024Article
- Reactivity of the 2-Methylfuran Phase I Metabolite 3-Acetylacrolein Toward DNA.Journal of agricultural and food chemistry · 2024Article
- Metabolically activated proteostasis regulators that protect against erastin-induced ferroptosis.RSC chemical biology · 2024Article
- A Novel Analog of the Natural Product Fraxinellone Protects against Endogenous and Exogenous Neurotoxicants.ACS chemical neuroscience · 2024Article
- Obacunone, a Promising Phytochemical Triterpenoid: Research Progress on Its Pharmacological Activity and Mechanism.Molecules (Basel, Switzerland) · 2024Review
- Synthesis of nimbolide and its analogues and their application as poly(ADP-ribose) polymerase-1 trapping inducers.Nature synthesis · 2024Article
- Draft genome sequence of furan-degradingMicrobiology resource announcements · 2024Article
- Natural Products and Pharmacological Properties of Symbiotic Bacillota (Firmicutes) of Marine Macroalgae.Marine drugs · 2023Review
1 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Many xenobiotics containing a furan ring are toxic and/or carcinogenic. The harmful effects of these compounds require furan ring oxidation. This reaction generates an electrophilic intermediate. Depending on the furan ring substituents, the intermediate is either an epoxide or a cis-enedione with more ring substitution favoring epoxide formation. Either intermediate reacts with cellular nucleophiles such as protein or DNA to trigger toxicities. The reactivity of the metabolite determines which cellular nucleophiles are targeted. The toxicity of a particular furan is also influenced by the presence of competing metabolic pathways or efficient detoxification routes. GSH plays an important role in modulating the harmful effects of this class of compound by reacting with the reactive metabolite. However, this may not represent a detoxification step in all cases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.