ArticleAddiction biology2014
Neural correlates of attentional bias for smoking cues: modulation by variance in the dopamine transporter gene.
Article in Addiction biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Orienting bias towards electronic nicotine delivery system (ENDS) cues.Addictive behaviors reports · 2026Article
- Effect of glucagon-like peptide-1 receptor agonists on cigarette smoking consumption in type 2 diabetes patients: study protocol of a randomized, parallel -controlled clinical trial.Frontiers in clinical diabetes and healthcare · 2026Article
- Brain and cortisol responses to smoking cues are linked in tobacco-smoking individuals.Addiction biology · 2023Article
- Impact of the natural hormonal milieu on ventral striatal responses to appetitive cigarette smoking cues: A prospective longitudinal study.Drug and alcohol dependence reports · 2022Article
- Influence of the natural hormonal milieu on brain and behavior in women who smoke cigarettes: Rationale and methodology.Contemporary clinical trials communications · 2021Article
- Association of Dopamine Transporter Gene with Heroin Dependence in an Indian Subpopulation from Manipur.Journal of molecular neuroscience : MN · 2021Article
- Contribution of Dopamine Transporter Gene Methylation Status to Cannabis Dependency.Brain sciences · 2020Article
- Classifying and characterizing nicotine use disorder with high accuracy using machine learning and resting-state fMRI.Addiction biology · 2019Article
- Multivariate pattern analysis of the neural correlates of smoking cue attentional bias.Pharmacology, biochemistry, and behavior · 2019Article
- The Influence of DAT1, COMT, and BDNF Genetic Polymorphisms on Total and Subregional Hippocampal Volumes in Early Onset Heavy Cannabis Users.Cannabis and cannabinoid research · 2018Article
- Individual variation in incentive salience attribution and accumbens dopamine transporter expression and function.The European journal of neuroscience · 2016Article
- Influence of menstrual cycle phase on resting-state functional connectivity in naturally cycling, cigarette-dependent women.Biology of sex differences · 2016Article
- Cannabis, Cigarettes, and Their Co-Occurring Use: Disentangling Differences in Gray Matter Volume.The international journal of neuropsychopharmacology · 2015Article
- Influence of menstrual cycle phase on neural and craving responses to appetitive smoking cues in naturally cycling females.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2015Article
- Biases of attention in chronic smokers: men and women are not alike.Cognitive, affective & behavioral neuroscience · 2014Article
- Article
- Individual variation in resisting temptation: implications for addiction.Neuroscience and biobehavioral reviews · 2013Review
- Neuroimaging in psychiatric pharmacogenetics research: the promise and pitfalls.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Review
- Gene x abstinence effects on drug cue reactivity in addiction: multimodal evidence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- GABA levels in the dorsal anterior cingulate cortex associated with difficulty ignoring smoking-related cues in tobacco-dependent volunteers.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Cigarette-dependent smokers automatically and involuntarily orient attention toward smoking cues (SCs). This attentional bias is clinically significant, as it may contribute to relapse. Thus, identifying neural and genetic correlates of attentional bias is critical for improving interventions. Our previous studies show that the dopamine transporter (DAT) SLC6A3 genotype exerts profound effects on limbic responses to SCs. One potential mechanism underlying these effects is greater attentional bias for SCs. Here, we explored associations between attentional bias for SCs and neural responses to SCs among 'sated' smokers genotyped for the SLC6A3 polymorphism. Pseudo-continuous arterial spin-labeled perfusion functional magnetic resonance imaging images were acquired during SC exposure in 35 smokers genotyped for the SLC6A3 variable number of tandem repeats polymorphism (n = 16, 9-repeats; n = 19, 10/10-repeats). Participants completed a visual dot-probe attentional bias task, which contained pictures of smoking and non-smoking pictures, to examine whether genetic variation in DAT influences attentional bias and to investigate relationships between attentional bias and neural responses to SCs. Although attentional bias to smoking pictures was not significantly different between 9-repeats and 10/10-repeats, 9-repeats showed a positive correlation between attentional bias and increased SC-induced brain activity in the amygdala, whereas 10/10-repeats showed an inverse correlation in the medial orbitofrontal cortex (mOFC). In group comparisons, 9-repeats exhibited positive correlations between attentional bias and SCs in the mOFC and amygdala, relative to 10/10-repeats. Findings suggest that genetic variation in the DAT gene influences brain responses associated with attentional bias; thus, providing additional support for a SC-vulnerable endophenotype.
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