Evidence map›Paper›PMID 23061393›Full record

ArticleJournal of neurosurgery2013

Symptomatic patients with intraluminal carotid artery thrombus: outcome with a strategy of initial anticoagulation.

Ananth K Vellimana, Yasha Kadkhodayan, Keith M Rich, DeWitte T Cross, Christopher J Moran, Allyson R Zazulia, Jin-Moo Lee, Michael R Chicoine, Ralph G Dacey, Colin P Derdeyn and 1 more

Abstract read
In one paragraph

Article in Journal of neurosurgery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 65 citations in OpenAlex.

  1. Review
  2. Emergent endovascular treatment versus medical treatment for acute large vessel occlusions with nondisabling symptoms.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2024
    Observational
  3. Review
  4. Article
  5. Article
  6. Article
  7. Anticoagulation and Stroke.Arquivos de neuro-psiquiatria · 2022
    Article
  8. Article
  9. Article
  10. Article
  11. Free-Floating Thrombus in the Distal Internal Carotid Artery Causing a Stroke.The International journal of angiology : official publication of the International College of Angiology, Inc · 2021
    Article
  12. Use of distal protection filter device for rescue mechanical thrombectomy for symptomatic free-floating thrombus of the cervical internal carotid artery.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2021
    Article
  13. Article
  14. Article
  15. Article
  16. Carotid Thrombosis in a Crack Cocaine Smoker Woman.Case reports in vascular medicine · 2020
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Ananth K VellimanaDepartment of Neurological Surgery, Washington University School of Medicine in St. Louis, Missouri 63110, USA.
Yasha Kadkhodayan
Keith M Rich
DeWitte T Cross
Christopher J Moran
Allyson R Zazulia
Jin-Moo Lee
Michael R Chicoine
Ralph G Dacey
Colin P Derdeyn
Gregory J Zipfel
Mallinckrodt (United States) · USNeurology, Inc · USNeurological Surgery · US

Funding

SAMMPRIS (Stenting vs. Aggressive Medical Management for Preventing . . .U01NS058728 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI CHIMOWITZ, MARC IVOR · 2008 to 2011
$20.0M
Washington University SPOTRIAS Center - Stroke Trials Registry / Web InterfaceP50NS055977 · NINDS · WASHINGTON UNIVERSITY · PI DERDEYN, COLIN PIETER · 2008 to 2012
$10.1M
The Role of Cerebral Hemodynamics in Moya Moya DiseaseR01NS051631 · NINDS · WASHINGTON UNIVERSITY · PI DERDEYN, COLIN PIETER · 2006 to 2010
$1.6M
NINDS NIH HHS P50 NS055977NINDS NIH HHS R01 NS051631NINDS NIH HHS U01 NS058728NINDS NIH HHS U01 NS58728
6 · The paper itself

Abstract

objectThe aim of this study was to define the optimal treatment for patients with symptomatic intraluminal carotid artery thrombus (ICAT).

methodsThe authors performed a retrospective chart review of patients who had presented with symptomatic ICAT at their institution between 2001 and 2011.

resultsTwenty-four patients (16 males and 8 females) with ICAT presented with ischemic stroke (18 patients) or transient ischemic attack ([TIA], 6 patients). All were initially treated using anticoagulation with or without antiplatelet drugs. Eight of these patients had no or only mild carotid artery stenosis on initial angiography and were treated with medical management alone. The remaining 16 patients had moderate or severe carotid stenosis on initial angiography; of these, 10 underwent delayed revascularization (8 patients, carotid endarterectomy [CEA]; 2 patients, angioplasty and stenting), 2 refused revascularization, and 4 were treated with medical therapy alone. One patient had multiple TIAs despite medical therapy and eventually underwent CEA; the remaining 23 patients had no TIAs after treatment. No patient suffered ischemic or hemorrhagic stroke while on anticoagulation therapy, either during the perioperative period or in the long-term follow-up; 1 patient died of an unrelated condition. The mean follow-up was 16.4 months.

conclusionsResults of this study suggest that initial anticoagulation for symptomatic ICAT leads to a low rate of recurrent ischemic events and that carotid revascularization, if indicated, can be safely performed in a delayed manner.

Indexed as

AdultAgedAnticoagulantsAspirinBrain IschemiaCarotid ArteriesCarotid Artery ThrombosisCarotid StenosisCerebral AngiographyEndarterectomy, CarotidFemaleHumansMaleMiddle AgedPlatelet Aggregation InhibitorsRetrospective StudiesAnticoagulantsAspirinPlatelet Aggregation InhibitorsWarfarin

Identifiers

PMID23061393
PMCPMC3868473
OpenAlexW1607221927

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.