ArticleCanadian journal of gastroenterology = Journal canadien de gastroenterologie2012
Esophageal cancer in Canada: trends according to morphology and anatomical location.
Article in Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Guideline on screening for esophageal adenocarcinoma in patients with chronic gastroesophageal reflux disease.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2020Guideline
- Global incidence of esophageal cancer by histological and anatomical subtypes.Nature communications · 2026Article
- Esophageal and Gastric Cancer Incidence and Mortality Trends in Norway, 1993-2022: A Registry-Based Study.Clinical epidemiology · 2025Article
- Outcomes from a single institution cohort of 248 patients with stage I-III esophageal cancer treated with radiotherapy: Comparison of younger and older populations.Technical innovations & patient support in radiation oncology · 2024Article
- Burden of esophageal cancer between 2010 and 2019 in Asian countries by geographical region and sociodemographic index: A comparison with global data.Thoracic cancer · 2023Article
- Update on cancer incidence trends in Canada, 1984 to 2017.Health promotion and chronic disease prevention in Canada : research, policy and practice · 2022Article
- Trends and projections in the incidence of oesophageal cancer in the Netherlands: An age-period-cohort analysis from 1989 to 2041.International journal of cancer · 2022Article
- Machines with vision for intraoperative guidance during gastrointestinal cancer surgery.Frontiers in medicine · 2022Article
- The Effect of Endoscopy on Patients with Malignant Esophageal Cancer after Medical Treatment and Chemotherapy.Computational and mathematical methods in medicine · 2022Article
- Article
- Development of a clinical score to distinguish malignant from benign esophageal disease in an undiagnosed patient population referred to an esophageal diagnostic assessment program.Journal of thoracic disease · 2020Article
- Review
- A Competing Risk Analysis Study of Prognosis in Patients with Esophageal Carcinoma 2006-2015 Using Data from the Surveillance, Epidemiology, and End Results (SEER) Database.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- High Content Imaging of Barrett's-Associated High-Grade Dysplasia Cells After siRNA Library Screening Reveals Acid-Responsive Regulators of Cellular Transitions.Cellular and molecular gastroenterology and hepatology · 2020Article
- Epidemiologic trends and geographic distribution of esophageal cancer in Canada: A national population-based study.Cancer medicine · 2020Article
- At-a-glance - Cancer trends in Canada, 1984 to 2015.Health promotion and chronic disease prevention in Canada : research, policy and practice · 2019Article
- Clinical diagnostic value of digestive endoscopic narrow-band imaging in early esophageal cancer.Oncology letters · 2019Article
- The white substance may be a potential endoscopic marker for flat esophageal mucosal neoplastic lesions: A new endoscopic observation.Medicine · 2018Article
- Trends and projections in adenocarcinoma and squamous cell carcinoma of the oesophagus in England from 1971 to 2037.British journal of cancer · 2018Article
- A pooled analysis of dietary sugar/carbohydrate intake and esophageal and gastric cardia adenocarcinoma incidence and survival in the USA.International journal of epidemiology · 2017Article
Corrections and comments
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Authors and funding
8 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEsophageal adenocarcinoma has one of the fastest rising incidence rates and one of the lowest survival rates of any cancer type in the Western world. However, in many countries, trends in esophageal cancer differ according to tumour morphology and anatomical location. In Canada, incidence and survival trends for esophageal cancer subtypes are poorly known.
methodsCancer incidence and mortality rates were obtained from the Canadian Cancer Registry, the National Cancer Incidence Reporting System and the Canadian Vital Statistics Death databases for the period from 1986 to 2006. Observed trends (annual per cent change) and five-year relative survival ratios were estimated separately for esophageal adenocarcinoma and squamous cell carcinoma, and according to location (upper, middle, or lower one-third of the esophagus). Incidence rates were projected up to the year 2026.
resultsAnnual age-standardized incidence rates for esophageal cancer in 2004 to 2006 were 6.1 and 1.7 per 100,000 for males and females, respectively. Esophageal adenocarcinoma incidence rose by 3.9% (males) and 3.6% (females) per year for the period 1986 to 2006, with the steepest increase in the lower one-third of the esophagus (4.8% and 5.0% per year among males and females, respectively). In contrast, squamous cell carcinoma incidence declined by 3.3% (males) and 3.2% (females) per year since the early 1990s. The five-year relative survival ratio for esophageal cancer was 13% between 2004 and 2006, approximately a 3% increase since the period from 1992 to 1994. Projected incidence rates showed increases of 40% to 50% for esophageal adenocarcinoma and decreases of 30% for squamous cell carcinoma by 2026. DISCUSSION: Although esophageal cancer is rare in Canada, the incidence of esophageal adenocarcinoma has doubled in the past 20 years, which may reflect the increasing prevalence of obesity and gastroesophageal reflux disease. Declines in squamous cell carcinoma may be the result of the decreases in the prevalence of smoking in Canada. Given the low survival rates and the potential for further increases in incidence, esophageal adenocarcinoma warrants close attention.
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