ArticleWorld journal of hepatology2012
Centrilobular necrosis in acute presentation of Japanese patients with type 1 autoimmune hepatitis.
Article in World journal of hepatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- Genuine acute autoimmune hepatitis has better therapeutic response and prognosis.Hepatology international · 2026Article
- Autoimmune hepatitis with confluent necrosis indicates severe liver injury but responds well to standard immunosuppressive therapy.Histology and histopathology · 2024Article
- Centrilobular zonal necrosis is a unique subtype of autoimmune hepatitis: A cohort study.Medicine · 2022Article
- Autoimmune Hepatitis with Acute Presentation: Clinical, Biochemical, and Histological Features of 126 Patients.Canadian journal of gastroenterology & hepatology · 2022Article
- The Asian Pacific Association for the Study of the Liver clinical practice guidance: the diagnosis and management of patients with autoimmune hepatitis.Hepatology international · 2021Article
- Clinical characteristics and treatment outcomes of acute severe autoimmune hepatitis.BMC gastroenterology · 2021Article
- Differences in autoimmune hepatitis based on inflammation localization.Medical molecular morphology · 2021Article
- Approach to the patient with acute severe autoimmune hepatitis.JHEP reports : innovation in hepatology · 2020Review
- Autoimmune Hepatitis: 2019 Update.Gut and liver · 2020Review
- Article
- Autoimmune Hepatitis in the Asia-Pacific Area.Journal of clinical and translational hepatology · 2018Review
- Acute Exacerbation to Autoimmune Hepatitis Mimicking Acute Viral Hepatitis-A Case Series and Review of Literature.Journal of clinical and experimental hepatology · 2018Article
- Centrilobular zonal necrosis as a hallmark of a distinctive subtype of autoimmune hepatitis.European journal of gastroenterology & hepatology · 2016Article
- Indian National Association for the Study of the Liver Consensus Statement on Acute Liver Failure (Part 1): Epidemiology, Pathogenesis, Presentation and Prognosis.Journal of clinical and experimental hepatologyReview
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Authors and funding
9 authors at 1 institution in 1 country.
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Abstract
aimTo compare clinicopathological features of acute presentation of type 1 autoimmune hepatitis (AIH) with or without centrilobular necrosis (CN).
methodsOur study comprised 41 patients with biopsy-proven acute presentation (acute exacerbation phase 36, acute hepatitis phase 5) of type 1 AIH at our hospital from 1975 to 2009. Elevated serum alanine aminotransferase (ALT) (> 5x upper limit of normal) identified acute presentation of the disease. We compared clinicopathological features of these AIH patients with or without CN. The data used for analysis included patient background (age, sex, type of disease, presence of complications with other autoimmune diseases, human leukocyte antigen, and International Autoimmune Hepatitis Group score), clinical parameters at presentation (ALT, alkaline phosphatase, IgG, anti-nuclear antibodies, and anti-smooth muscle antibodies), histology and therapy.
resultsCN was found in 13 (31.7%) patients with acute presentation (acute exacerbation phase 10, acute hepatitis phase 3) of AIH. Serum IgG levels of patients with CN were significantly lower than those of patients without CN (mean: 2307 mg/dL vs 3126 mg/dL, P < 0.05), while antinuclear antibody-negative rates were significantly higher (30.7% vs 3.5%, P < 0.05). However, other clinical features were similar between the two groups. The frequency of advanced fibrosis in patients with CN was significantly lower than in patients without CN (F0-2: 84.6% vs 35.7%, F3-4: 15.4% vs 64.3%, P < 0.05). Other histological features were similar between the two groups. Although there was no significant difference between groups when evaluated using the revised original score (12 vs 14), the simplified AIH score of patients with CN was significantly lower (6 vs 7, P < 0.05). Frequency of DR4 was similar between patients with and without CN.
conclusionCN is observed in both Japanese patients with acute hepatitis phase and acute exacerbation phase of type 1 AIH, although AIH with CN often shows clinical features of the genuine acute form.
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