ArticleCommunicative & integrative biology2012
The planar cell polarity protein VANGL2 coordinates remodeling of the extracellular matrix.
Article in Communicative & integrative biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- DCLK1-mediated regulation of invadopodia dynamics and matrix metalloproteinase trafficking drives invasive progression in head and neck squamous cell carcinoma.Molecular cancer · 2025Article
- Extracellular vesicles and particles as mediators of long-range communication in cancer: connecting biological function to clinical applications.Extracellular vesicles and circulating nucleic acids · 2023Article
- Wnt signaling in biliary development, proliferation, and fibrosis.Experimental biology and medicine (Maywood, N.J.) · 2022Review
- Vangl as a Master Scaffold for Wnt/Planar Cell Polarity Signaling in Development and Disease.Frontiers in cell and developmental biology · 2022Review
- Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors.Nature communications · 2020Article
- VANGL2 interacts with integrin αv to regulate matrix metalloproteinase activity and cell adhesion to the extracellular matrix.Experimental cell research · 2017Article
- A tectorin-based matrix and planar cell polarity genes are required for normal collagen-fibril orientation in the developing tectorial membrane.Development (Cambridge, England) · 2017Article
- HeterozygousDisease models & mechanisms · 2017Article
- Article
- Invadosomes in their natural habitat.European journal of cell biology · 2014Review
- Vangl1 and Vangl2: planar cell polarity components with a developing role in cancer.Endocrine-related cancer · 2014Review
- Trafficking mechanisms of extracellular matrix macromolecules: insights from vertebrate development and human diseases.The international journal of biochemistry & cell biology · 2014Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding how planar cell polarity (PCP) is established, maintained, and coordinated in migrating cell populations is an important area of research with implications for both embryonic morphogenesis and tumor cell invasion. We recently reported that the PCP protein Vang-like 2 (VANGL2) regulates the endocytosis and cell surface level of membrane type-1 matrix metalloproteinase (MMP14 or MT1-MMP). Here, we further discuss these findings in terms of extracellular matrix (ECM) remodeling, cell migration, and zebrafish gastrulation. We also demonstrate that VANGL2 function impacts the focal degradation of ECM by human cancer cells including the formation or stability of invadopodia. Together, our findings implicate MMP14 as a downstream effector of VANGL2 signaling and suggest a model whereby the regulation of pericellular proteolysis is a fundamental aspect of PCP in migrating cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.