ArticleFrontiers in plant science2012
Global SUMO Proteome Responses Guide Gene Regulation, mRNA Biogenesis, and Plant Stress Responses.
Article in Frontiers in plant science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Viral RNA polymerase as a SUMOylation decoy inhibits RNA quality control to promote potyvirus infection.Nature communications · 2025Article
- Functional transcriptome analysis revealed major changes in pathways affecting systems biology of Tharparkar cattle under seasonal heat stress.3 Biotech · 2024Article
- The conjugation of SUMO to the transcription factor MYC2 functions in blue light-mediated seedling development in Arabidopsis.The Plant cell · 2022Article
- SUMO E3 ligase SIZ1 connects sumoylation and reactive oxygen species homeostasis processes in Arabidopsis.Plant physiology · 2022Article
- Review
- qPTMplants: an integrative database of quantitative post-translational modifications in plants.Nucleic acids research · 2022Article
- Plant responses to geminivirus infection: guardians of the plant immunity.Virology journal · 2021Review
- The SUMO E3 Ligase SIZ1 Negatively Regulates Shoot Regeneration.Plant physiology · 2020Article
- Proteasomal degradation of BRAHMA promotes Boron tolerance in Arabidopsis.Nature communications · 2018Article
- Geminivirus Replication Protein Impairs SUMO Conjugation of Proliferating Cellular Nuclear Antigen at Two Acceptor Sites.Journal of virology · 2018Article
- Arabidopsis thaliana SPF1 and SPF2 are nuclear-located ULP2-like SUMO proteases that act downstream of SIZ1 in plant development.Journal of experimental botany · 2018Article
- Arabidopsis TCP Transcription Factors Interact with the SUMO Conjugating Machinery in Nuclear Foci.Frontiers in plant science · 2017Article
- Rapid identification of ubiquitination and SUMOylation target sites by microfluidic peptide array.Biochemistry and biophysics reports · 2016Article
- Posttranslational Modifications of the Master Transcriptional Regulator NPR1 Enable Dynamic but Tight Control of Plant Immune Responses.Cell host & microbe · 2015Article
- Arabidopsis PIAL1 and 2 promote SUMO chain formation as E4-type SUMO ligases and are involved in stress responses and sulfur metabolism.The Plant cell · 2014Article
- Weighing up the possibilities: Controlling translation by ubiquitylation and sumoylation.Translation (Austin, Tex.) · 2014Review
- The function of EHD2 in endocytosis and defense signaling is affected by SUMO.Plant molecular biology · 2014Article
- New clues in the nucleus: transcriptional reprogramming in effector-triggered immunity.Frontiers in plant science · 2013Review
- Global analysis of SUMO chain function reveals multiple roles in chromatin regulation.The Journal of cell biology · 2013Article
- Editorial: Mechanisms regulating immunity in plants.Frontiers in plant science · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Small Ubiquitin-like MOdifier (SUMO) is a key regulator of abiotic stress, disease resistance, and development in plants. The identification of >350 plant SUMO targets has revealed many processes modulated by SUMO and potential consequences of SUMO on its targets. Importantly, highly related proteins are SUMO-modified in plants, yeast, and metazoans. Overlapping SUMO targets include heat-shock proteins (HSPs), transcription regulators, histones, histone-modifying enzymes, proteins involved in DNA damage repair, but also proteins involved in mRNA biogenesis and nucleo-cytoplasmic transport. Proteomics studies indicate key roles for SUMO in gene repression by controlling histone (de)acetylation activity at genomic loci. The responsible heavily sumoylated transcriptional repressor complexes are recruited by plant transcription factors (TFs) containing an (ERF)-associated Amphiphilic Repression (EAR) motif. These TFs are not necessarily themselves a SUMO target. Conversely, SUMO acetylation (Ac) prevents binding of downstream partners by blocking binding of their SUMO-interaction peptide motifs to Ac-SUMO. In addition, SUMO acetylation has emerged as a mechanism to recruit specifically bromodomains. Bromodomains are generally linked with gene activation. These findings strengthen the idea of a bi-directional sumo-acetylation switch in gene regulation. Quantitative proteomics has highlighted that global sumoylation provides a dynamic response to protein damage involving SUMO chain-mediated protein degradation, but also SUMO E3 ligase-dependent transcription of HSP genes. With these insights in SUMO function and novel technical advancements, we can now study SUMO dynamics in responses to (a)biotic stress in plants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.