ArticleFrontiers in physiology2012
Are mouse models of asthma appropriate for investigating the pathogenesis of airway hyper-responsiveness?
Article in Frontiers in physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 51 citations in OpenAlex.
- RCT of the effect of berryfruit polyphenolic cultivar extract in mild steroid-naive asthma: a cross-over, placebo-controlled study.BMJ open · 2017Trial
- The gut-lung axis: effects and mechanisms of gut microbiota on pulmonary diseases.Frontiers in immunology · 2025Review
- Review
- Different Phenotypes in Asthma: Clinical Findings and Experimental Animal Models.Clinical reviews in allergy & immunology · 2022Review
- Short and dysfunctional telomeres protect from allergen-induced airway inflammation.Aging cell · 2021Article
- Review
- Azelastine potentiates antiasthmatic dexamethasone effect on a murine asthma model.Pharmacology research & perspectives · 2019Article
- Endomorphin-2- and Neurotensin- Based Chimeric Peptide Attenuates Airway Inflammation in Mouse Model of Nonallergic Asthma.International journal of molecular sciences · 2019Article
- Article
- Review
- Chronic features of allergic asthma are enhanced in the absence of resistin-like molecule-beta.Scientific reports · 2018Article
- Developmental pathways in lung regeneration.Cell and tissue research · 2017Review
- A NovelJournal of infectious pulmonary diseases · 2017Article
- 15-Deoxy-Delta-12,14-Prostaglandin JFrontiers in immunology · 2017Article
- Emerging concepts in smooth muscle contributions to airway structure and function: implications for health and disease.American journal of physiology. Lung cellular and molecular physiology · 2016Review
- Administration of JTE013 abrogates experimental asthma by regulating proinflammatory cytokine production from bronchial epithelial cells.Respiratory research · 2016Article
- Eosinophils, galectins, and a reason to breathe.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Bronchial epithelium in children: a key player in asthma.European respiratory review : an official journal of the European Respiratory Society · 2016Review
- Bronchial lesions of mouse model of asthma are preceded by immune complex vasculitis and induced bronchial associated lymphoid tissue (iBALT).Laboratory investigation; a journal of technical methods and pathology · 2015Article
- Emerging molecular phenotypes of asthma.American journal of physiology. Lung cellular and molecular physiology · 2015Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Whether mouse models of chronic asthma can be used to investigate the relationship between airway inflammation/remodeling and airway hyper-responsiveness (AHR) is a vexed question. It raises issues about the extent to which such models replicate key features of the human disease. Here, we review some of the characteristic pathological features of human asthma and their relationship to AHR and examine some limitations of mouse models that are commonly used to investigate these relationships. We compare these conventional models with our mouse model of chronic asthma involving long-term low-level inhalational challenge and review studies of the relationship between inflammation/remodeling and AHR in this model and its derivatives, including models of an acute exacerbation of chronic asthma and of the induction phase of childhood asthma. We conclude that while extrapolating from studies in mouse models to AHR in humans requires cautious interpretation, such experimental work can provide significant insights into the pathogenesis of airway responsiveness and its molecular and cellular regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.