ArticleMetabolomics : Official journal of the Metabolomic Society2012
A lipidomic analysis approach to evaluate the response to cholesterol-lowering food intake.
Article in Metabolomics : Official journal of the Metabolomic Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 45 citations in OpenAlex.
- Trial
- Plasma lipidomic profiles after a low and high glycemic load dietary pattern in a randomized controlled crossover feeding study.Metabolomics : Official journal of the Metabolomic Society · 2020Trial
- Lipidomic changes of LDL in overweight and moderately hypercholesterolemic subjects taking phytosterol- and omega-3-supplemented milk.Journal of lipid research · 2015Trial
- Dietary intake of palmitate and oleate has broad impact on systemic and tissue lipid profiles in humans.The American journal of clinical nutrition · 2014Trial
- Lipid mediator serum profiles in asthmatics significantly shift following dietary supplementation with omega-3 fatty acids.Molecular nutrition & food research · 2013Trial
- Review
- Circulating Lipid Profiles Indicate Incomplete Metabolic Recovery After Weight Loss, Suggesting the Need for Additional Interventions in Severe Obesity.Biomolecules · 2025Article
- Effects of wolfberry (Frontiers in nutrition · 2024Article
- Serum lipidome analysis of healthy beagle dogs receiving different diets.Metabolomics : Official journal of the Metabolomic Society · 2019Article
- Pro-Resolving Lipid Mediators in the Pathophysiology of Asthma.Medicina (Kaunas, Lithuania) · 2019Review
- The Effects of Age and Reproduction on the Lipidome ofOxidative medicine and cellular longevity · 2019Article
- Systems biology approaches to understand the effects of nutrition and promote health.British journal of clinical pharmacology · 2017Review
- A metabolomic and pharmacokinetic study on the mechanism underlying the lipid-lowering effect of orally administered berberine.Molecular bioSystems · 2015Article
- Lipidomic analysis of serum from high fat diet induced obese mice.International journal of molecular sciences · 2014Article
- Nutritional lipidomics: molecular metabolism, analytics, and diagnostics.Molecular nutrition & food research · 2013Review
- Assessing the metabolic effects of prednisolone in healthy volunteers using urine metabolic profiling.Genome medicine · 2012Article
- Changes in urine headspace composition as an effect of strenuous walking.Metabolomics : Official journal of the Metabolomic SocietyArticle
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant sterols (PS) are well known to reduce serum levels of total cholesterol and LDL-cholesterol. Lipidomics potentially provides detailed information on a wide range of individual serum lipid metabolites, which may further add to our understanding of the biological effects of PS. In this study, lipidomics analysis was applied to serum samples from a placebo-controlled, parallel human intervention study (n = 97) of 4-week consumption of two PS-enriched, yoghurt drinks differing in fat content (based on 0.1% vs. 1.5% dairy fat). A comprehensive data analysis strategy was developed and implemented to assess and compare effects of two different PS-treatments and placebo treatment. The combination of univariate and multivariate data analysis approaches allowed to show significant effects of PS intake on the serum lipidome, and helped to distinguish them from fat content and non-specific effects. The PS-enriched 0.1% dairy fat yoghurt drink had a stronger impact on the lipidome than the 1.5% dairy fat yoghurt drink, despite similar LDL-cholesterol lowering effects. The PS-enriched 0.1% dairy fat yoghurt drink reduced levels of several sphingomyelins which correlated well with the reduction in LDL-cholesterol and can be explained by co-localization of sphingomyelins and cholesterol on the surface of LDL lipoprotein. Statistically significant reductions in serum levels of two lysophosphatidylcholines (LPC(16:1), LPC(20:1)) and cholesteryl arachidonate may suggest reduced inflammation and atherogenic potential. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11306-011-0384-2) contains supplementary material, which is available to authorized users.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.