ArticleThe European respiratory journal2013
Potential implication of new torque teno mini viruses in parapneumonic empyema in children.
Article in The European respiratory journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- Clinical outcome of parapneumonic empyema in children treated according to a standardized medical treatment.European journal of pediatrics · 2014Trial
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- Large expansion of plasma commensal viruses is associated with SIV pathogenesis inScience advances · 2024Article
- Structure of anellovirus-like particles reveal a mechanism for immune evasion.Nature communications · 2024Article
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- Taxonomic update for mammalian anelloviruses (family Anelloviridae).Archives of virology · 2021Article
- Occurrence and quantification of Anelloviruses and Herpesviruses in gingival tissue in Chinese Shanghai sub-population.BMC oral health · 2020Article
- Dual infection and recombination of Kaposi sarcoma herpesvirus revealed by whole-genome sequence analysis of effusion samples.Virus evolution · 2020Article
- Human anelloviruses: diverse, omnipresent and commensal members of the virome.FEMS microbiology reviews · 2020Review
- Epidemiology and Phylogenetic Analysis of Viral Respiratory Infections in Vietnam.Frontiers in microbiology · 2020Article
- Identification of a Torque Teno Mini Virus (TTMV) in Hodgkin's Lymphoma Patients.Frontiers in microbiology · 2018Article
- Virome and bacteriome characterization of children with pneumonia and asthma in Mexico City during winter seasons 2014 and 2015.PloS one · 2018Article
- Detection of a new species of torque teno mini virus from the gingival epithelium of patients with periodontitis.Virus genes · 2017Article
- Etiology of parapneumonic effusion and pleural empyema in children. The role of conventional and molecular microbiological tests.Respiratory medicine · 2016Observational
- A novel species of torque teno mini virus (TTMV) in gingival tissue from chronic periodontitis patients.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An unexplained increase in the incidence of parapneumonic empyema (PPE) in pneumonia cases has been reported in recent years. The present study investigated the genetic and biological specifications of new isolates of torque teno mini virus (TTMV) detected in pleural effusion samples from children hospitalised for severe pneumonia with PPE. A pathogen discovery protocol was applied in undiagnosed pleural effusion samples and led to the identification of three new isolates of TTMV (TTMV-LY). Isolated TTMV-LY genomes were transfected into A549 and human embryonic kidney 293T cells and viral replication was assessed by quantitative real-time PCR and full-length genome amplification. A549 cells were further infected with released TTMV-LY virions and the induced-innate immune response was measured by multiplex immunoassays. Genetic analyses of the three TTMV-LY genomes revealed a classic genomic organisation but a weak identity (<64%) with known sequences. We demonstrated the in vitro replication of TTMV-LY in alveolar epithelial cells and the effective release of infectious viral particles. We also showed a selective production of inflammatory mediators in response to TTMV infection. This study reports the description of replicative TTMV-LY isolated from parapneumonic effusions of children hospitalised with PPE, suggesting a potential role of the virus in the pathogenesis of pneumonia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.