ArticleThe Journal of biological chemistry2012
Biochemical characterization of P4-ATPase mutations identified in patients with progressive familial intrahepatic cholestasis.
Article in The Journal of biological chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Yeast and human P4-ATPases transport glycosphingolipids using conserved structural motifs.The Journal of biological chemistry · 2019Article
- Spectrum of genomic variations in Indian patients with progressive familial intrahepatic cholestasis.BMC gastroenterology · 2018Article
- Disease mutations reveal residues critical to the interaction of P4-ATPases with lipid substrates.Scientific reports · 2017Article
- Current and future therapies for inherited cholestatic liver diseases.World journal of gastroenterology · 2017Review
- SRT1720 Alleviates ANIT-Induced Cholestasis in a Mouse Model.Frontiers in pharmacology · 2017Article
- Different Mutations in a P-type ATPase Transporter in Leishmania Parasites are Associated with Cross-resistance to Two Leading Drugs by Distinct Mechanisms.PLoS neglected tropical diseases · 2016Article
- Directed evolution of a sphingomyelin flippase reveals mechanism of substrate backbone discrimination by a P4-ATPase.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Phospholipid flippase activities and substrate specificities of human type IV P-type ATPases localized to the plasma membrane.The Journal of biological chemistry · 2014Article
- P4-ATPases: lipid flippases in cell membranes.Pflugers Archiv : European journal of physiology · 2014Review
- P4 ATPases: flippases in health and disease.International journal of molecular sciences · 2013Review
- Phospholipase D2 mediates signaling by ATPase class I type 8B membrane 1.Journal of lipid research · 2013Article
- Decoding P4-ATPase substrate interactions.Critical reviews in biochemistry and molecular biologyReview
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Mutations in the P4-ATPase ATP8B1 cause the inherited liver disease progressive familial intrahepatic cholestasis. Several of these mutations are located in conserved regions of the transmembrane domain associated with substrate binding and transport. Assays for P4-ATPase-mediated transport in living yeast cells were developed and used to characterize the specificity and kinetic parameters of this transport. Progressive familial intrahepatic cholestasis mutations were introduced into the yeast plasma membrane P4-ATPase Dnf2p, and the effect of these mutations on its catalysis of phospholipid transport were determined. The results of these measurements have implications for the basis of the disease and for the mechanism of phospholipid transit through the enzyme during the reaction cycle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.