ArticleBMC cancer2012
Inflammatory gene variants and the risk of biliary tract cancers and stones: a population-based study in China.
Article in BMC cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- SNTB1 gene polymorphisms and risk of high myopia: meta-analysis and single-center validation.Molecular vision · 2025Pooled it
- Meta-analyses of the relationship between five CXCL8 gene polymorphisms and overall cancer risk, and a case-control study of oral cancer.BMC oral health · 2024Pooled it
- Association of inflammatory and other immune markers with gallbladder cancer: Results from two independent case-control studies.Cytokine · 2016Trial
- Genetic variants in VEGF gene family enhance colorectal cancer susceptibility via modulating metabolic pathways.Archives of toxicology · 2026Article
- The Association Between IL-8 Gene Polymorphisms and the Risk of Several Types of Cancer, Especially in Gastric Cancer.Cancer reports (Hoboken, N.J.) · 2025Article
- The Role of Inflammatory Biomarkers in Mediating the Effect of Inflammatory Bowel Disease on nonmalignant Digestive System Diseases: A Multivariable Mendelian Randomized Study.Canadian journal of gastroenterology & hepatology · 2024Article
- Genetic association of MMP14 promoter variants and their functional significance in gallbladder cancer pathogenesis.Journal of human genetics · 2021Article
- Association of Cholecystectomy with the Risk of Prostate Cancer in Patients with Gallstones.Cancers · 2020Article
- Gallbladder cancer epidemiology, pathogenesis and molecular genetics: Recent update.World journal of gastroenterology · 2017Review
- Lipopolysaccharide-pathway proteins are associated with gallbladder cancer among adults in Shanghai, China with mediation by systemic inflammation.Annals of epidemiology · 2016Article
- Association between gallbladder stone disease and prostate cancer: A nationwide population-based study.Oncotarget · 2016Article
- The inflammatory inception of gallbladder cancer.Biochimica et biophysica acta · 2016Review
- Essential role of polymorphism of Gab1, EGFR, and EGF for the susceptibility of biliary tract cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Gastrointestinal stromal tumors: a case-only analysis of single nucleotide polymorphisms and somatic mutations.Clinical sarcoma research · 2013Article
Corrections and comments
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Authors and funding
15 authors at 9 institutions in 2 countries.
Funding
Abstract
backgroundGenetic variants in inflammation-related genes have been associated with biliary stones and biliary tract cancers in previous studies.
methodsTo follow-up on these findings, we examined 35 single nucleotide polymorphism (SNPs) in 5 genes related to inflammation (IL8, NFKBIL, RNASEL, TNF, and VEGFA) in 456 participants with incident biliary tract cancer cases (262 gallbladder, 141 extrahepatic bile duct, 53 ampulla of Vater), 982 participants with biliary stones, and 860 healthy controls in a population-based case-control study in Shanghai, China.
resultsSuggestive associations were observed for SNPs in VEGFA with biliary stones, IL8 with gallbladder and ampulla of Vater cancers, and RNASEL with ampulla of Vater cancer (false discovery rate≤0.2).
conclusionThese findings provide additional support for the role of inflammation in biliary stones and biliary tract cancer risk and need further validation.
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