ReviewThe journal of knee surgery2012
Toward engineering a biological joint replacement.
Review in The journal of knee surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- A latent TGF-β conjugated scaffold improves neocartilage development.Acta biomaterialia · 2026Article
- A Systems Approach to Biomechanics, Mechanobiology, and Biotransport.Journal of biomechanical engineering · 2024Article
- Modernizing Storage Conditions for Fresh Osteochondral Allografts by Optimizing Viability at Physiologic Temperatures and Conditions.Cartilage · 2021Article
- The porcine accessory carpal bone as a model for biologic joint replacement for trapeziometacarpal osteoarthritis.Acta biomaterialia · 2021Article
- Raman Spectroscopy: Guiding Light for the Extracellular Matrix.Frontiers in bioengineering and biotechnology · 2019Review
- A modular approach to creating large engineered cartilage surfaces.Journal of biomechanics · 2018Article
- Raman spectroscopic imaging for quantification of depth-dependent and local heterogeneities in native and engineered cartilage.NPJ Regenerative medicine · 2018Article
- Online quantitative monitoring of live cell engineered cartilage growth using diffuse fiber-optic Raman spectroscopy.Biomaterials · 2017Article
- Enhanced nutrient transport improves the depth-dependent properties of tri-layered engineered cartilage constructs with zonal co-culture of chondrocytes and MSCs.Acta biomaterialia · 2017Article
- Human chondrocyte migration behaviour to guide the development of engineered cartilage.Journal of tissue engineering and regenerative medicine · 2017Article
- Enhanced depth-independent chondrocyte proliferation and phenotype maintenance in an ultrasound bioreactor and an assessment of ultrasound dampening in the scaffold.Acta biomaterialia · 2014Article
- Effect of long-term osmotic loading culture on matrix synthesis from intervertebral disc cells.BioResearch open access · 2014Article
- Nanocomposite scaffold for chondrocyte growth and cartilage tissue engineering: effects of carbon nanotube surface functionalization.Tissue engineering. Part A · 2014Article
- Time and dose-dependent effects of chondroitinase ABC on growth of engineered cartilage.European cells & materials · 2014Article
- Animal models of cartilage repair.Bone & joint research · 2014Article
- Trends in biological joint resurfacing.Bone & joint research · 2013Article
- Trimethylamine N-oxide as a media supplement for cartilage tissue engineering.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
Osteoarthritis is a major cause of disability and pain for patients in the United States. Treatments for this degenerative disease represent a significant challenge considering the poor regenerative capacity of adult articular cartilage. Tissue-engineering techniques have advanced over the last two decades such that cartilage-like tissue can be cultivated in the laboratory for implantation. Even so, major challenges remain for creating fully functional tissue. This review article overviews some of these challenges, including overcoming limitations in nutrient supply to cartilage, improving in vitro collagen production, improving integration of engineered cartilage with native tissue, and exploring the potential for engineering full articular surface replacements.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.