ArticleIranian journal of pediatrics2011
The role of IL-6 for predicting neonatal sepsis: a systematic review and meta-analysis.
Article in Iranian journal of pediatrics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06199102 (The High Initial Dose of Monitored Vitamin D Supplementation in Preterm Infants. A Randomized Controlled Study.), which is not on this map. Cited by 28 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The High Initial Dose of Monitored Vitamin D Supplementation in Preterm Infants. A Randomized Controlled Study.
Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Interleukin-6 for early diagnosis of neonatal sepsis with premature rupture of the membranes: A meta-analysis.Medicine · 2018Pooled it
- Serum interleukin-6 in the diagnosis of bacterial infection in cirrhotic patients: A meta-analysis.Medicine · 2016Pooled it
- Inflammatory markers in cord blood or maternal serum for early detection of neonatal sepsis-a systemic review and meta-analysis.Journal of perinatology : official journal of the California Perinatal Association · 2014Pooled it
- The Predictive Value of Umbilical Cord Interleukin-6: Implications for Neonatal Care-A Narrative Review of Current Evidence and Future Perspectives.Life (Basel, Switzerland) · 2025Review
- Mechanical stretch promotes sustained proliferation and inflammation in developing human airway smooth muscle.American journal of physiology. Lung cellular and molecular physiology · 2025Article
- The Role of IL-6 in the Diagnosis of Neonatal Sepsis and Its Influence on Maternal Mental Health.Cureus · 2025Article
- Umbilical cord blood level of interleukins used as a predictor of early-onset neonatal sepsis: a comprehensive review.Frontiers in cellular and infection microbiology · 2025Review
- Diagnostic accuracy of interleukin-6 in multiple diseases: An umbrella review of meta-analyses.Heliyon · 2024Review
- High Initial Dose of Monitored Vitamin D Supplementation in Preterm Infants (HIDVID Trial): Study Protocol for a Randomized Controlled Study.Nutrients · 2024Article
- Molecularly Imprinted Polymer-Based Electrochemical Sensors for the Diagnosis of Infectious Diseases.Biosensors · 2023Review
- Serum YKL-40 as a Potential Biomarker for Sepsis in Term Neonates-A Pilot Study.Children (Basel, Switzerland) · 2023Article
- Repositioning linifanib as a potent anti-necroptosis agent for sepsis.Cell death discovery · 2023Article
- Prospective multicentre study of host response signatures in neonatal sepsis in Sub Saharan Africa.Scientific reports · 2022Article
- Biomarker combinations in predicting sepsis in hospitalized children with fever.BMC pediatrics · 2022Article
- Clinical Application of Serum Inflammatory Factors Combined with Dynamic Detection in the Diagnosis and Treatment of Neonatal Sepsis.Iranian journal of public health · 2021Article
- Sepsis Diagnostics: Intensive Care Scoring Systems Superior to MicroRNA Biomarker Testing.Diagnostics (Basel, Switzerland) · 2020Article
- Elevated Interleukin-6 Levels within 72 Hours Post Admission Are Associated with Disease Progression in Nonseptic Critically Ill Children.BioMed research international · 2020Article
- The Pathogenesis of Sepsis and Potential Therapeutic Targets.International journal of molecular sciences · 2019Review
- Potential biomarkers for neuroinflammation and neurodegeneration at short and long term after neonatal hypoxic-ischemic insult in rat.Journal of neuroinflammation · 2019Article
- Neonatal Sepsis.Current emergency and hospital medicine reports · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveNeonatal sepsis (NS) is a common and life-threatening disorder in infants. Previous studies showed that interleukin-6 (IL-6) may be a valid non-invasive and rapid method for diagnosis of NS. We conducted this review to assess the validity of IL-6 for predicting NS.
methodsThis was a systematic review with meta-analysis. Embase, Medline and Web of Science databases were searched between January 1990 and December 2009. The search terms used were "cytokine", "neonate", "sepsis" and "interleukin-6". We used standard methods recommended for meta analyses of diagnostic test evaluations. The analysis was based on a summary ROC (SROC) curve. Meta-regression analysis was used to assess the effects of some confounding factors on the results of meta-analysis. Potential presence of publication bias was tested using funnel plots and the Egger test.
findingsMeta-analysis was performed on 13 publications including 353 infants with sepsis and 691 control infants. The pooled sensitivity and specificity of IL-6 was 0.79 and 0.84, respectively. The maximum joint sensitivity and specificity (i.e., the Q value) in SROC curve was 0.82 and the area under curve (AUC) was 0.89 (95% CI: 0.84-0.94). Meta-regression analysis showed that the diagnostic accuracy of IL-6 was not affected by confounding variables. The evaluation of publication bias showed that the Egger test was not significant (P=0.07).
conclusionIL-6 seems to be a valid marker for predicting NS. It may be considered for early diagnosis of sepsis in neonatal care units.
Indexed as
Identifiers
23056824PMC3446138W2163973620What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.