ArticlePloS one2012
Genomic diversity of Escherichia isolates from diverse habitats.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 48 citations in OpenAlex.
- Do Sanitation Improvements Reduce Fecal Contamination of Water, Hands, Food, Soil, and Flies? Evidence from a Cluster-Randomized Controlled Trial in Rural Bangladesh.Environmental science & technology · 2018Trial
- Diversity of Environmental Escherichia coli in Subtropical Freshwater Systems of South Africa.Current microbiology · 2025Article
- A multi-pathogen behavioral exposure model for young children playing in public spaces in developing communities.PLoS neglected tropical diseases · 2024Article
- Basin-scale biogeography of Prochlorococcus and SAR11 ecotype replication.The ISME journal · 2023Article
- Genetic Determinants of Escherichia coli Survival in Beach Sand.Applied and environmental microbiology · 2023Article
- Phosphate solubilizing bacteria from soils with varying environmental conditions: Occurrence and function.PloS one · 2023Article
- Environmental impacts of mass drug administration programs: exposures, risks, and mitigation of antimicrobial resistance.Infectious diseases of poverty · 2022Review
- Is It Human or Animal? The Origin of PathogenicTropical medicine and infectious disease · 2021Article
- Selective survival ofApplied and environmental microbiology · 2021Article
- Measuring Environmental Exposure to Enteric Pathogens in Low-Income Settings: Review and Recommendations of an Interdisciplinary Working Group.Environmental science & technology · 2020Review
- Microbial Indicators of Fecal Pollution: Recent Progress and Challenges in Assessing Water Quality.Current environmental health reports · 2020Review
- Human fecal contamination of water, soil, and surfaces in households sharing poor-quality sanitation facilities in Maputo, Mozambique.International journal of hygiene and environmental health · 2020Article
- Predictors of Enteric Pathogens in the Domestic Environment from Human and Animal Sources in Rural Bangladesh.Environmental science & technology · 2019Article
- Microbial Community Enhances Biodegradation of Bisphenol A Through Selection of Sphingomonadaceae.Microbial ecology · 2019Article
- The distribution of bacterial doubling times in the wild.Proceedings. Biological sciences · 2018Article
- Whole genome sequencing of ESBL-producing Escherichia coli isolated from patients, farm waste and canals in Thailand.Genome medicine · 2017Article
- Animal Feces Contribute to Domestic Fecal Contamination: Evidence from E. coli Measured in Water, Hands, Food, Flies, and Soil in Bangladesh.Environmental science & technology · 2017Article
- Culture independent analysis using gnd as a target gene to assess Escherichia coli diversity and community structure.Scientific reports · 2017Article
- "Wigglesworthia morsitans" Folate (Vitamin B9) Biosynthesis Contributes to Tsetse Host Fitness.Applied and environmental microbiology · 2015Article
- Adhesion of marine cryptic Escherichia isolates to human intestinal epithelial cells.The ISME journal · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our understanding of the Escherichia genus is heavily biased toward pathogenic or commensal isolates from human or animal hosts. Recent studies have recovered Escherichia isolates that persist, and even grow, outside these hosts. Although the environmental isolates are typically phylogenetically distinct, they are highly related to and phenotypically indistinguishable from their human counterparts, including for the coliform test. To gain insights into the genomic diversity of Escherichia isolates from diverse habitats, including freshwater, soil, animal, and human sources, we carried out comparative DNA-DNA hybridizations using a multi-genome E. coli DNA microarray. The microarray was validated based on hybridizations with selected strains whose genome sequences were available and used to assess the frequency of microarray false positive and negative signals. Our results showed that human fecal isolates share two sets of genes (n>90) that are rarely found among environmental isolates, including genes presumably important for evading host immune mechanisms (e.g., a multi-drug transporter for acids and antimicrobials) and adhering to epithelial cells (e.g., hemolysin E and fimbrial-like adhesin protein). These results imply that environmental isolates are characterized by decreased ability to colonize host cells relative to human isolates. Our study also provides gene markers that can distinguish human isolates from those of warm-blooded animal and environmental origins, and thus can be used to more reliably assess fecal contamination in natural ecosystems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.