ArticlePloS one2012
Aging contributes to inflammation in upper extremity tendons and declines in forelimb agility in a rat model of upper extremity overuse.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Profibrotic mediators in tendon disease: a systematic review.Arthritis research & therapy · 2016Pooled it
- Overuse injury induces persistent behavioral declines that correlate with higher IL-6 expression in the affected musculoskeletal tissues, circulation, and brain.Frontiers in physiology · 2025Article
- Repetitive Overuse Injury Causes Entheseal Damage and Palmar Muscle Fibrosis in Older Rats.International journal of molecular sciences · 2024Article
- LeveragingFrontiers in bioengineering and biotechnology · 2024Review
- Impact of aging on tendon homeostasis, tendinopathy development, and impaired healing.Connective tissue research · 2023Review
- Inhibition of IKKβ/NF-κB signaling facilitates tendinopathy healing by rejuvenating inflamm-aging induced tendon-derived stem/progenitor cell senescence.Molecular therapy. Nucleic acids · 2022Article
- Tendon healing is adversely affected by low-grade inflammation.Journal of orthopaedic surgery and research · 2021Review
- Tendinopathy and tendon material response to load: What we can learn from small animal studies.Acta biomaterialia · 2021Review
- Local shifts in inflammatory and resolving lipid mediators in response to tendon overuse.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Key indicators of repetitive overuse-induced neuromuscular inflammation and fibrosis are prevented by manual therapy in a rat model.BMC musculoskeletal disorders · 2021Article
- Bringing tendon biology to heel: Leveraging mechanisms of tendon development, healing, and regeneration to advance therapeutic strategies.Developmental dynamics : an official publication of the American Association of Anatomists · 2021Review
- Reparative and Maladaptive Inflammation in Tendon Healing.Frontiers in bioengineering and biotechnology · 2021Review
- Manual Therapy With Rest as a Treatment for Established Inflammation and Fibrosis in a Rat Model of Repetitive Strain Injury.Frontiers in physiology · 2021Article
- Evaluation of animal models and methods for assessing shoulder function after rotator cuff tear: A systematic review.Journal of orthopaedic translation · 2021Review
- The shift in macrophages polarisation after tendon injury: A systematic review.Journal of orthopaedic translation · 2020Review
- Regulatory mechanisms and clinical manifestations of musculoskeletal aging.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019Review
- Article
- Biology of Tendon Stem Cells and Tendon in Aging.Frontiers in genetics · 2019Review
- Calcium Fluxes in Work-Related Muscle Disorder: Implications from a Rat Model.BioMed research international · 2019Article
- Cytokines in tendon disease: A Systematic Review.Bone & joint research · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
We sought to determine if tendon inflammatory and histopathological responses increase in aged rats compared to young rats performing a voluntary upper extremity repetitive task, and if these changes are associated with motor declines. Ninety-six female Sprague-Dawley rats were used in the rat model of upper extremity overuse: 67 aged and 29 young adult rats. After a training period of 4 weeks, task rats performed a voluntary high repetition low force (HRLF) handle-pulling task for 2 hrs/day, 3 days/wk for up to 12 weeks. Upper extremity motor function was assessed, as were inflammatory and histomorphological changes in flexor digitorum and supraspinatus tendons. The percentage of successful reaches improved in young adult HRLF rats, but not in aged HRLF rats. Forelimb agility decreased transiently in young adult HRLF rats, but persistently in aged HRLF rats. HRLF task performance for 12 weeks lead to increased IL-1beta and IL-6 in flexor digitorum tendons of aged HRLF rats, compared to aged normal control (NC) as well as young adult HRLF rats. In contrast, TNF-alpha increased more in flexor digitorum tendons of young adult 12-week HRLF rats than in aged HRLF rats. Vascularity and collagen fibril organization were not affected by task performance in flexor digitorum tendons of either age group, although cellularity increased in both. By week 12 of HRLF task performance, vascularity and cellularity increased in the supraspinatus tendons of only aged rats. The increased cellularity was due to increased macrophages and connective tissue growth factor (CTGF)-immunoreactive fibroblasts in the peritendon. In conclusion, aged rat tendons were overall more affected by the HRLF task than young adult tendons, particularly supraspinatus tendons. Greater inflammatory changes in aged HRLF rat tendons were observed, increases associated temporally with decreased forelimb agility and lack of improvement in task success.
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Registered trials
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