ArticlePloS one2012
Neural processing of emotional facial and semantic expressions in euthymic bipolar disorder (BD) and its association with theory of mind (ToM).
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Enhanced Neural Decoding With Optically Pumped Magnetometer MEG Using Multivariate Pattern Analysis.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026Article
- Social cognition in first-degree relatives of bipolar disorder: Theory of Mind and nonverbal sensitivity.PloS one · 2021Article
- Time to Face Language: Embodied Mechanisms Underpin the Inception of Face-Related Meanings in the Human Brain.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Theory of mind in remitted bipolar disorder: Interpersonal accuracy in recognition of dynamic nonverbal signals.PloS one · 2019Article
- Social neuroscience: undoing the schism between neurology and psychiatry.Social neuroscience · 2018Review
- A lesion model of envy and Schadenfreude: legal, deservingness and moral dimensions as revealed by neurodegeneration.Brain : a journal of neurology · 2017Article
- Altered N170 and mood symptoms in bipolar disorder: An electrophysiological study of configural face processing.Bipolar disorders · 2017Article
- The relationship between executive functions and fluid intelligence in euthymic Bipolar Disorder patients.Psychiatry research · 2017Article
- Dysfunctional gaze processing in bipolar disorder.NeuroImage. Clinical · 2017Article
- From neural signatures of emotional modulation to social cognition: individual differences in healthy volunteers and psychiatric participants.Social cognitive and affective neuroscience · 2014Article
- Mindfulness based cognitive therapy may improve emotional processing in bipolar disorder: pilot ERP and HRV study.Metabolic brain disease · 2014Article
- Facial emotion recognition in first-episode schizophrenia and bipolar disorder with psychosis.Schizophrenia research · 2014Article
- Neuropsychology, social cognition and global functioning among bipolar, schizophrenic patients and healthy controls: preliminary data.Frontiers in human neuroscience · 2013Article
- Attachment patterns trigger differential neural signature of emotional processing in adolescents.PloS one · 2013Article
Corrections and comments
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Authors and funding
18 authors.
Funding
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Abstract
backgroundAdults with bipolar disorder (BD) have cognitive impairments that affect face processing and social cognition. However, it remains unknown whether these deficits in euthymic BD have impaired brain markers of emotional processing. METHODOLOGY/PRINCIPAL
findingsWe recruited twenty six participants, 13 controls subjects with an equal number of euthymic BD participants. We used an event-related potential (ERP) assessment of a dual valence task (DVT), in which faces (angry and happy), words (pleasant and unpleasant), and face-word simultaneous combinations are presented to test the effects of the stimulus type (face vs word) and valence (positive vs. negative). All participants received clinical, neuropsychological and social cognition evaluations. ERP analysis revealed that both groups showed N170 modulation of stimulus type effects (face > word). BD patients exhibited reduced and enhanced N170 to facial and semantic valence, respectively. The neural source estimation of N170 was a posterior section of the fusiform gyrus (FG), including the face fusiform area (FFA). Neural generators of N170 for faces (FG and FFA) were reduced in BD. In these patients, N170 modulation was associated with social cognition (theory of mind). CONCLUSIONS/SIGNIFICANCE: This is the first report of euthymic BD exhibiting abnormal N170 emotional discrimination associated with theory of mind impairments.
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