ArticlePloS one2012
Macrophages improve survival, proliferation and migration of engrafted myogenic precursor cells into MDX skeletal muscle.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Generation of Phd2-haplodeficient macrophages with proresolution effects for the treatment of limb ischemia.Frontiers in pharmacology · 2025Article
- Unsaturated Long-Chain Fatty Acids Activate Resident Macrophages and Stem Cells in a Human Skeletal Muscle Tissue Model.Biology · 2023Article
- Pharmacological inhibition of HDAC6 improves muscle phenotypes in dystrophin-deficient mice by downregulating TGF-β via Smad3 acetylation.Nature communications · 2022Article
- Translating musculoskeletal bioengineering into tissue regeneration therapies.Science translational medicine · 2022Review
- Transplantation to study satellite cell heterogeneity in skeletal muscle.Frontiers in cell and developmental biology · 2022Review
- Macrophages in Skeletal Muscle Dystrophies, An Entangled Partner.Journal of neuromuscular diseases · 2022Review
- Macrophages and Stem Cells-Two to Tango for Tissue Repair?Biomolecules · 2021Review
- Stem cell therapy for muscular dystrophies.The Journal of clinical investigation · 2020Review
- Irradiation dependent inflammatory response may enhance satellite cell engraftment.Scientific reports · 2020Article
- Fibrosis following Acute Skeletal Muscle Injury: Mitigation and Reversal Potential in the Clinic.Journal of sports medicine (Hindawi Publishing Corporation) · 2020Review
- Crosstalk Between Innate and T Cell Adaptive Immunity With(in) the Muscle.Frontiers in physiology · 2020Review
- A Promising Future for Stem-Cell-Based Therapies in Muscular Dystrophies-In Vitro and In Vivo Treatments to Boost Cellular Engraftment.International journal of molecular sciences · 2019Review
- Incorporation of macrophages into engineered skeletal muscle enables enhanced muscle regeneration.Nature biomedical engineering · 2018Article
- Why is Skeletal Muscle Regeneration Impaired after Myonecrosis Induced by Viperid Snake Venoms?Toxins · 2018Review
- Expression of Wnt/β-catenin related genes after skeletal muscle contusion.International journal of clinical and experimental pathology · 2018Article
- Neuroendocrine Control of Macrophage Development and Function.Frontiers in immunology · 2018Review
- Timed Delivery of Therapy Enhances Functional Muscle Regeneration.Advanced healthcare materials · 2017Article
- Induced migration of endothelial cells into 3D scaffolds by chemoattractants secreted by pro-inflammatory macrophagesRegenerative biomaterials · 2017Article
- Retinoic acid maintains human skeletal muscle progenitor cells in an immature state.Cellular and molecular life sciences : CMLS · 2017Article
- Therapeutic potential of adipose-derived stem cells and macrophages for ischemic skeletal muscle repair.Regenerative medicine · 2017Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transplantation of muscle precursor cells is of therapeutic interest for focal skeletal muscular diseases. However, major limitations of cell transplantation are the poor survival, expansion and migration of the injected cells. The massive and early death of transplanted myoblasts is not fully understood although several mechanisms have been suggested. Various attempts have been made to improve their survival or migration. Taking into account that muscle regeneration is associated with the presence of macrophages, which are helpful in repairing the muscle by both cleansing the debris and deliver trophic cues to myoblasts in a sequential way, we attempted in the present work to improve myoblast transplantation by coinjecting macrophages. The present data showed that in the 5 days following the transplantation, macrophages efficiently improved: i) myoblast survival by limiting their massive death, ii) myoblast expansion within the tissue and iii) myoblast migration in the dystrophic muscle. This was confirmed by in vitro analyses showing that macrophages stimulated myoblast adhesion and migration. As a result, myoblast contribution to regenerating host myofibres was increased by macrophages one month after transplantation. Altogether, these data demonstrate that macrophages are beneficial during the early steps of myoblast transplantation into skeletal muscle, showing that coinjecting these stromal cells may be used as a helper to improve the efficiency of parenchymal cell engraftment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.