ArticlePloS one2012
Cancer stem cell-related gene periostin: a novel prognostic marker for breast cancer.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 75 citations in OpenAlex.
- Triple negative breast tumors in African-American and Hispanic/Latina women are high in CD44+, low in CD24+, and have loss of PTEN.PloS one · 2013Trial
- A label-free microLC-SWATH-MS methodology with immunoaffinity depletion of highly abundant serum proteins for quantitative proteomic comparison of fresh-frozen human normal breast tissue and tumor clinical specimens.Frontiers in molecular biosciences · 2026Article
- Expression of periostin and podoplanin in canine testicular tumours.BMC veterinary research · 2025Article
- Inflammation-driven periostin in ECRS has contrasting effects on tissue structural integrity and osteitis.Frontiers in immunology · 2025Article
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- Article
- MicroRNA-206 suppresses growth and metastasis of breast cancer stem cells via blocking EVI-1-mediated CALR expression.PloS one · 2022Article
- Article
- Development of an engineered peptide antagonist against periostin to overcome doxorubicin resistance in breast cancer.BMC cancer · 2021Article
- Periostin: An Emerging Molecule With a Potential Role in Spinal Degenerative Diseases.Frontiers in medicine · 2021Review
- Review
- Expression of Osteoblast-Specific Factor 2 (OSF-2, Periostin) Is Associated with Drug Resistance in Ovarian Cancer Cell Lines.International journal of molecular sciences · 2019Article
- Fibulin-2 is required for basement membrane integrity of mammary epithelium.Scientific reports · 2018Article
- Prognostic value of periostin in early-stage breast cancer treated with conserving surgery and radiotherapy.Oncology letters · 2018Article
- Periostin overexpression is associated with worse prognosis in nasopharyngeal carcinoma from endemic area: a cohort study.OncoTargets and therapy · 2018Article
- The multifaceted role of periostin in priming the tumor microenvironments for tumor progression.Cellular and molecular life sciences : CMLS · 2017Review
- Do the expressions of epithelial-mesenchymal transition proteins, periostin, integrin-α4 and fibronectin correlate with clinico-pathological features and prognosis of metastatic castration-resistant prostate cancer?Experimental biology and medicine (Maywood, N.J.) · 2017Article
- Epithelial periostin expression is correlated with poor survival in patients with invasive breast carcinoma.PloS one · 2017Article
- Heterogeneous Periostin Expression in Different Histological Variants of Papillary Thyroid Carcinoma.BioMed research international · 2017Article
- High levels of periostin correlate with increased fracture rate, diffuse MRI pattern, abnormal bone remodeling and advanced disease stage in patients with newly diagnosed symptomatic multiple myeloma.Blood cancer journal · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the expression status of periostin in breast cancer stem cells and its clinical implications in order to lay a foundation for managing breast cancer. CD44+/CD24-/line- tumor cells (CSC) from clinical specimens were sorted using flow cytometry. Periostin expression status was detected in CSC cells and 1,086 breast cancer specimens by Western blot and immunohistochemistry staining, with the CSC ratio determined by immunofluorescence double staining. The relationship between the periostin protein and clinico-pathological parameters and prognosis was subsequently determined. As a result, CSC cells are more likely to generate new tumors in mice and cell microspheres that are deficient in NOD/SCID compared to the control group. Periostin protein was expressed higher in CSC cells compared to the control cells and was found to be related to CSC chemotherapy resistance. Moreover, periostin expression was found to be related to the CSC ratio in 1,086 breast cancer specimens (P = 0.001). In total, 334 (30.76%) of the 1,086 breast cases showed high periostin expression. After universal and Spearman regression correlation analysis, periostin was observed to be related to histological grade, CSC ratio, lymph node metastasis, tumor size, and triple-negative breast cancer (all P<0.05). Furthermore, periostin was shown to attain a significantly more distant bone metastasis and worse disease-specific survival than those with none or low-expressed periostin protein (P = 0.001). In the Cox regression test, periostin protein was detected as an independent prognostic factor (P = 0.001). In conclusion, periostin was found to be related to the CSC and an independent prognostic factor for breast cancer. It is also perhaps a potential target to breast cancer.
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