ArticlePloS one2012
Linkage disequilibrium decay and past population history in the human genome.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
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- Genetic Diversity, Population Structure and Selection Signature in Begait Goats Revealed by Whole-Genome Sequencing.Animals : an open access journal from MDPI · 2024Article
- Genomic prediction based on a joint reference population for the Xinjiang Brown cattle.Frontiers in genetics · 2024Article
- The flashfm approach for fine-mapping multiple quantitative traits.Nature communications · 2021Article
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- Population-specific long-range linkage disequilibrium in the human genome and its influence on identifying common disease variants.Scientific reports · 2019Article
- Genome-Wide Linkage Disequilibrium and the Extent of Effective Population Sizes in Six Chinese Goat Populations Using a 50K Single Nucleotide Polymorphism Panel.Animals : an open access journal from MDPI · 2019Article
- Mapping Recombination Rate on the Autosomal Chromosomes Based on the Persistency of Linkage Disequilibrium Phase Among Autochthonous Beef Cattle Populations in Spain.Frontiers in genetics · 2019Article
- Latitudinal Clines of the Human Vitamin D Receptor and Skin Color Genes.G3 (Bethesda, Md.) · 2016Article
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- Human gephyrin is encompassed within giant functional noncoding yin-yang sequences.Nature communications · 2015Article
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- Effective population size of korean populations.Genomics & informatics · 2014Article
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1 author at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The fluctuation of population size has not been well studied in the previous studies of theoretical linkage disequilibrium (LD) expectation. In this study, an improved theoretical prediction of LD decay was derived to account for the effects of changes in effective population sizes. The equation was used to estimate effective population size (N(e)) assuming a constant N(e) and LD at equilibrium, and these N(e) estimates implied the past changes of N(e) for a certain number of generations until equilibrium, which differed based on recombination rate. As the influence of recent population history on the N(e) estimates is larger than old population history, recent changes in population size can be inferred more accurately than old changes. The theoretical predictions based on this improved expression showed accurate agreement with the simulated values. When applied to human genome data, the detailed recent history of human populations was obtained. The inferred past population history of each population showed good correspondence with historical studies. Specifically, four populations (three African ancestries and one Mexican ancestry) showed population growth that was significantly less than that of other populations, and two populations originated from China showed prominent exponential growth. During the examination of overall LD decay in the human genome, a selection pressure on chromosome 14, the gephyrin gene, was observed in all populations.
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