ArticlePloS one2012
Dab2ip regulates neuronal migration and neurite outgrowth in the developing neocortex.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- DAB2IP: unifying cardiovascular pathogenesis and cardiovascular brain crosstalk.Frontiers in cardiovascular medicine · 2026Review
- Urine miRNA signature as potential non-invasive diagnostic biomarker for Hirschsprung's disease.Frontiers in molecular neuroscience · 2024Article
- ZebrafishFrontiers in molecular neuroscience · 2024Article
- Maf1 is an intrinsic suppressor against spontaneous neural repair and functional recovery after ischemic stroke.Journal of advanced research · 2023Article
- DNA methylation and exposure to violence among African American young adult males.Brain, behavior, & immunity - health · 2021Article
- Pumping the brakes on RAS - negative regulators and death effectors of RAS.Journal of cell science · 2020Review
- Disabled homolog 2 interactive protein functions as a tumor suppressor in osteosarcoma cells.Oncology letters · 2018Article
- Importin-8 Modulates Division of Apical Progenitors, Dendritogenesis and Tangential Migration During Development of Mouse Cortex.Frontiers in molecular neuroscience · 2018Article
- Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.Scientific reports · 2017Article
- Neuronal Polarity in the Embryonic Mammalian Cerebral Cortex.Frontiers in cellular neuroscience · 2017Review
- Decoding the molecular mechanisms of neuronal migration using in utero electroporation.Medical molecular morphology · 2016Review
- New Insights into Reelin-Mediated Signaling Pathways.Frontiers in cellular neuroscience · 2016Review
- Canonical and Non-canonical Reelin Signaling.Frontiers in cellular neuroscience · 2016Review
- Expression of mouse Dab2ip transcript variants and gene methylation during brain development.Gene · 2015Article
- Dab2IP Regulates Neuronal Positioning, Rap1 Activity and Integrin Signaling in the Developing Cortex.Developmental neuroscience · 2015Article
- Molecular Pathways Underlying Projection Neuron Production and Migration during Cerebral Cortical Development.Frontiers in neuroscience · 2015Review
- Article
- WONOEP appraisal: new genetic approaches to study epilepsy.Epilepsia · 2014Review
- Article
- Dab2IP GTPase activating protein regulates dendrite development and synapse number in cerebellum.PloS one · 2013Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Dab2ip (DOC-2/DAB2 interacting protein) is a member of the Ras GTPase-activating protein (GAP) family that has been previously shown to function as a tumor suppressor in several systems. Dab2ip is also highly expressed in the brain where it interacts with Dab1, a key mediator of the Reelin pathway that controls several aspects of brain development and function. We found that Dab2ip is highly expressed in the developing cerebral cortex, but that mutations in the Reelin signaling pathway do not affect its expression. To determine whether Dab2ip plays a role in brain development, we knocked down or over expressed it in neuronal progenitor cells of the embryonic mouse neocortex using in utero electroporation. Dab2ip down-regulation severely disrupts neuronal migration, affecting preferentially late-born principal cortical neurons. Dab2ip overexpression also leads to migration defects. Structure-function experiments in vivo further show that both PH and GRD domains of Dab2ip are important for neuronal migration. A detailed analysis of transfected neurons reveals that Dab2ip down- or up-regulation disrupts the transition from a multipolar to a bipolar neuronal morphology in the intermediate zone. Knock down of Dab2ip in neurons ex-vivo indicates that this protein is necessary for proper neurite development and for the expression of several major neuronal microtubule associated proteins (MAPs), which are important for neurite growth and stabilization. Thus, our study identifies, for the first time, a critical role for Dab2ip in mammalian cortical development and begins to reveal molecular mechanisms that underlie this function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.