ArticlePloS one2012
Increasing blood glucose variability is a precursor of sepsis and mortality in burned patients.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Glycemic variability improves risk prediction and reveals a mortality threshold in orthopedic trauma patients with sepsis.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2026Article
- Associations of Diabetes and Hyperglycaemia with Extent and Outcomes of Acute Burn Injuries.Biomedicines · 2024Article
- Intensive insulin therapy in sepsis patients: Better data enables better intervention.Heliyon · 2023Review
- Expert consensus on the glycemic management of critically ill patients.Journal of intensive medicine · 2022Article
- History of diabetes may delay antibiotic administration in patients with severe sepsis presenting to emergency departments.Medicine · 2020Article
- Glycemic Variability: An Independent Predictor of Mortality and the Impact of Age in Pediatric Intensive Care Unit.Frontiers in pediatrics · 2020Article
- Statistical Properties and Predictability of Extreme Epileptic Events.Scientific reports · 2019Article
- Article
- Continuous Glucose Monitoring in Resource-Constrained Settings for Hypoglycaemia Detection: Looking at the Problem from the Other Side of the Coin.Biosensors · 2018Article
- Higher In vitro Proliferation Rate of Rhizopus oryzae in Blood of Diabetic Individuals in Chronic Glycaemic Control Compared with Non-diabetic Individuals.Mycopathologia · 2017Article
- Microenvironmental cooperation promotes early spread and bistability of a Warburg-like phenotype.Scientific reports · 2017Article
- Simulation and qualitative analysis of glucose variability, mean glucose, and hypoglycemia after subcutaneous insulin therapy for stress hyperglycemia.Theoretical biology & medical modelling · 2016Article
- Establishment and Validation of GV-SAPS II Scoring System for Non-Diabetic Critically Ill Patients.PloS one · 2016Article
- Hypoglycemia and Risk Factors for Death in 13 Years of Pediatric Admissions in Mozambique.The American journal of tropical medicine and hygiene · 2016Article
- Glycemic control in critically ill: A moving target.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2014Review
- Article
- Observational
- Clinical review: Glucose control in severely burned patients - current best practice.Critical care (London, England) · 2013Review
- Glycemic variability is an independent predictive factor for development of hepatic fibrosis in nonalcoholic fatty liver disease.PloS one · 2013Article
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
High glycemic variability, rather than a mean glucose level, is an important factor associated with sepsis and hospital mortality in critically ill patients. In this retrospective study we analyze the blood glucose data of 172 nondiabetic patients 18-60 yrs old with second and third-degree burns of total body surface area greater than 30% and 5%, respectively, admitted to ICU in 2004-2008. The analysis identified significant association of increasing daily glucose excursion (DELTA) accompanied by evident episodes of hyperglycemia (>11 mmol/l) and hypoglycemia (<2.8 mmol/l), with sepsis and forthcoming death, even when the mean daily glucose was within a range of acceptable glycemia. No association was found in sepsis complication and hospital mortality with doses of intravenous insulin and glucose infusion. A strong increase in DELTA before sepsis and death is treated as fluctuation amplification near the onset of dynamical instability.
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