ArticleComputational and mathematical methods in medicine2012
Simulation of arrhythmogenic effect of rogue RyRs in failing heart by using a coupled model.
Article in Computational and mathematical methods in medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Reduced gap junction coupling amplifies the effects of cardiomyocyte variability and destabilizes the heartbeat.Physiological reports · 2025Article
- An Electromechanical Model-Based Study on the Dosage Effects of Ranolazine in Treating Failing HCM Cardiomyocyte.Cellular and molecular bioengineering · 2025Article
- Effects of rogue ryanodine receptors on CaRoyal Society open science · 2018Article
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Cardiac cells with heart failure are usually characterized by impairment of Ca(2+) handling with smaller SR Ca(2+) store and high risk of triggered activities. In this study, we developed a coupled model by integrating the spatiotemporal Ca(2+) reaction-diffusion system into the cellular electrophysiological model. With the coupled model, the subcellular Ca(2+) dynamics and global cellular electrophysiology could be simultaneously traced. The proposed coupled model was then applied to study the effects of rogue RyRs on Ca(2+) cycling and membrane potential in failing heart. The simulation results suggested that, in the presence of rogue RyRs, Ca(2+) dynamics is unstable and Ca(2+) waves are prone to be initiated spontaneously. These release events would elevate the membrane potential substantially which might induce delayed afterdepolarizations or triggered action potentials. Moreover, the variation of membrane potential depolarization is indicated to be dependent on the distribution density of rogue RyR channels. This study provides a new possible arrhythmogenic mechanism for heart failure from subcellular to cellular level.
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